Document Detail


Risk assessment in elderly for sensitization to food and respiratory allergens.
MedLine Citation:
PMID:  16876879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For elderly people, epidemiological data are rare for respiratory allergies and completely missing for food allergies. The aim of this study was to examine the prevalence and risk factors for sensitizations in 109 people with a mean age of 77 years, who are living in a geriatric nursing home. The cross-sectional study included a detailed interview, skin prick tests, and serum tests for specific and total IgE, IFN-gamma, and ST2, a marker for Th2-lymphocyte activity. Almost all study subjects (n=101) suffered from co-morbidity, 14 from type I allergy, 25 from gastrointestinal disorders treated with anti-ulcer drugs, 25 were chronic alcoholics and 21 were smokers. The total IgE levels were significantly higher in men (P=0.025), and not affected by smoking or alcohol consumption. Skin prick tests were positive in 41.7% of tested patients. Specific IgE to respiratory allergens was found in 40.4% of all patients and was elevated in men (P=0.013), with a significant correlation to smoking (P=0.029). Specific IgE to food allergens was detected in 24.8%, apparently without connection to the investigated risk factors. However, positive skin prick tests with food allergens could be correlated with chronic alcohol consumption (P=0.036). The intake of anti-ulcer medication was significantly correlated with elevated ST2 levels as an indirect readout for Th2-cell activity (P<0.001). The risk factors for sensitization in elderly to respiratory allergens were chronic damage of respiratory epithelia due to smoking, and for sensitization to food allergens chronic alcohol consumption.
Authors:
Noemi Bakos; Isabella Schöll; Krisztina Szalai; Michael Kundi; Eva Untersmayr; Erika Jensen-Jarolim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-10
Journal Detail:
Title:  Immunology letters     Volume:  107     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-12     Completed Date:  2006-11-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Hetenyi Geza Hospital, Szolnok, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alcohol Drinking / adverse effects
Allergens
Anti-Ulcer Agents / immunology,  pharmacology
Cross-Sectional Studies
Female
Food Hypersensitivity / epidemiology,  immunology*
Humans
Immunoglobulin E / blood
Interferon-gamma / blood
Male
Middle Aged
Prevalence
Receptors, Cell Surface / blood
Respiratory Hypersensitivity / epidemiology,  immunology*
Risk Factors
Skin Tests
Smoking / adverse effects
Chemical
Reg. No./Substance:
0/Allergens; 0/Anti-Ulcer Agents; 0/IL1RL1 protein, human; 0/Receptors, Cell Surface; 37341-29-0/Immunoglobulin E; 82115-62-6/Interferon-gamma

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