| Risk assessment and genetic testing for ovarian cancer. | |
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MedLine Citation:
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PMID: 20093589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Prevention of ovarian cancer starts with identifying women at high risk for this deadly disease. Once identified, these women can be offered risk-reducing options such as oral contraceptives and bilateral salpingo-oophorectomy. In this review, strategies for identifying high-risk individuals and the clinical utility of genetic testing for BRCA1 and BRCA2 will be discussed. CONCLUSION: To offer potentially life-saving interventions for at-risk family members, we propose that every woman newly diagnosed with ovarian cancer be offered genetic testing for BRCA1 and BRCA2 genes because mutations in these genes are the strongest known predictors of ovarian cancer risk. |
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Authors:
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Cassandra Gulden; Olufunmilayo I Olopade |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 194 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 309-10 Citation Subset: AIM; IM |
Affiliation:
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Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Genes, BRCA1* Genes, BRCA2* Genetic Testing* Humans Mutation Ovarian Neoplasms / genetics*, prevention & control* Risk Assessment / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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