Document Detail

Risk assessment of dietary acrylamide intake in Flemish adolescents.
MedLine Citation:
PMID:  15621340     Owner:  NLM     Status:  MEDLINE    
Acrylamide has recently been found in a range of heat treated food items. As it is a neurotoxic agent and a probable, human carcinogen (IARC 2A), human exposure to this chemical might constitute an important public health issue. The purpose of the study was to estimate the acrylamide intake in Flemish adolescents (based on 7-day food record) and to evaluate the possible health risks due to the exposure. The Belgian Federal Agency for the Safety of the Food Chain collected 150 food items from different supermarkets and restaurants to analyse the acrylamide level. The limit of quantitation was 30 microg acrylamide/kg foodstuffs. Exposure modelling was based on Monte Carlo simulations. The estimated dietary intake of acrylamide per person given as the 5th, 50th and 95th percentile were 0.19, 0.51 and 1.09 mircog/kg bw/d. Bread, despite its low acrylamide content, is relevant as a source of acrylamide exposure at the lower percentiles. At higher percentiles the contribution of French fries and crisps is more important. It must be emphasised that the exposure assessment has several limitations. Risk of neurotoxicity seems negligible. The relevance of current intake levels in terms of cancer risk remains a subject of debate.
C Matthys; M Bilau; Y Govaert; E Moons; S De Henauw; J L Willems
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  43     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
Department of Public Health, Ghent University, UZ-2 Blok A, De Pintelaan 185, B-9000 Ghent, Belgium.
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MeSH Terms
Acrylamide / administration & dosage*,  adverse effects,  analysis
Carcinogens / administration & dosage*,  adverse effects,  analysis
Consumer Product Safety
Cookery / methods
Diet Records
Diet Surveys*
Food Analysis
Monte Carlo Method
Neurotoxins / administration & dosage*,  adverse effects,  analysis
Risk Assessment
Reg. No./Substance:
0/Carcinogens; 0/Neurotoxins; 79-06-1/Acrylamide

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