Document Detail

Risk assessment of bisphenol A migrated from canned foods in Korea.
MedLine Citation:
PMID:  20077204     Owner:  NLM     Status:  MEDLINE    
Exposure and risk assessment of bisphenol A (BPA) was conducted on consumption of canned foods in Korean adults. Sixty-one canned food items with different brands purchased from retail outlets in markets were analyzed for BPA concentration by high-performance liquid chromatography (HPLC) coupled with fluorescence detection. Limits of detection (LOD) were 3 microg/kg for solid and 2 microg/kg for liquid foods. BPA was detected from 7 groups of food items, such as tuna (n = 8), fish (n = 11), fruits (n = 9), vegetables (n = 12), meats (n = 13), coffee (n = 5), and tea (n = 3) in the range from not detected (ND) to 136.14 microg/kg. Mean concentrations of BPA were 3.1 microg/kg (ND-21.5 microg/kg) for vegetables, 8.3 microg/kg (ND-14.26) for tea, 8.6 microg/kg (ND-54.56 microg/kg) for fruits, 24.49 microg/kg (ND-98.30 microg/kg) for meats, 39.78 microg/kg (ND-125.25 microg/kg) for fish, 43.7 microg/kg (ND-116.88 microg/kg) for tuna, and 45.51 microg/kg (ND-136.14 microg/kg) for coffee, in the order of magnitude. Based on daily dietary intake of canned food items and concentrations of BPA, human exposure level to BPA was estimated to be 1.509 microg/kg body weight (bw)/d, well below the tolerable daily intake (TDI) or reference dose (RfD) of 50 microg/kg, bw/d set by the European Commission, U.S.EPA, and South Korea. Therefore, the potential risk for BPA contamination due to consumption of each canned food items was calculated to be (1.509 microg/kg bw/d)/(50 microg/kg bw/d) = 0.03, which is the hazard index [HI = exposure level/(RfD or TDI)]. Evidence indicates that the levels of BPA levels in canned foods are not likely to constitute a safety concern for consumers in Korea.
Duck Soo Lim; Seung Jun Kwack; Kyu-Bong Kim; Hyung Sik Kim; Byung Mu Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  72     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  1327-35     Citation Subset:  IM    
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-Do, South Korea.
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MeSH Terms
Environmental Exposure
Estrogens, Non-Steroidal / chemistry*
Food Handling
Food, Preserved / analysis*
Fruit / chemistry
Meat / analysis
Molecular Structure
Phenols / chemistry*
Republic of Korea
Risk Factors
Vegetables / chemistry
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Phenols; 80-05-7/bisphenol A

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