Document Detail

Risk assessment of aflatoxins in food in Africa.
MedLine Citation:
PMID:  18608489     Owner:  NLM     Status:  MEDLINE    
Aflatoxins are secondary metabolites of the fungi Aspergillus flavus and A. parasiticus, occur widely on many staple foods and cause a broad range of detrimental health effects in animals and humans. As a consequence, maximum tolerated levels (MTLs) have been legislated in many countries. However, in developing countries where food safety compliance can be low and significant levels of the food supply are locally consumed by the producers or purchased at local markets, more comprehensive strategies are required. In this regard, risk analysis with its components of risk assessment, risk management and risk communication, is an important tool in dealing with food safety issues. Risk assessment for aflatoxin B(1) in Africa has been performed using the carcinogenic potency, established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and applying it to typical food products and consumption across the continent, to illustrate the significant health implications caused by the intake of high levels of contaminated foods. Highlighted in this assessment is the fact that even low levels of contamination, which might of themselves fall within legislated limits, can have serious health implications due to high levels of consumption, i.e. meeting a MTL does not of itself guarantee food safety. Recent developments have highlighted the growth retardation and immune suppression caused by aflatoxin exposure in human populations in west Africa. Using the limited data available on both these health effects, a first step has been taken to incorporate them into a risk assessment paradigm quantifying the risk of immunosuppression, malnutrition and stunting in children exposed to aflatoxins and highlighting again how excessive consumption of foods meeting MTLs can carry significant health risks.
Gordon S Shephard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  25     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-19     Completed Date:  2008-12-05     Revised Date:  2009-08-13    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  1246-56     Citation Subset:  IM    
PROMEC Unit, Medical Research Council, Tygerberg 7505, South Africa.
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MeSH Terms
Aflatoxin B1 / toxicity*
Body Weight
Environmental Exposure
Food Contamination / analysis
Growth Disorders / chemically induced*
Immunotoxins / toxicity*
Malnutrition / chemically induced*
Maximum Allowable Concentration
Risk Assessment / methods
Reg. No./Substance:
0/Immunotoxins; 1162-65-8/Aflatoxin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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