Document Detail


Risk assessment of acrylamide in foods.
MedLine Citation:
PMID:  12805639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daily mean intakes of acrylamide present in foods and coffee in a limited Norwegian exposure assessment study have been estimated to be 0.49 and 0.46 microg per kg body weight in males and females, respectively. Testicular mesotheliomas and mammary gland adenomas have consistently been found in 2-year drinking water rat cancer studies with acrylamide. Acrylamide also shows initiating activity in mouse skin after systemic administration. Since acrylamide is converted to the mutagenic metabolite glycidamide and forms adducts to hemoglobin in rodents and humans, the tumorigenic endpoints in rats were assumed to be an expression of acrylamide genotoxicity. Using the default linear extrapolation methods LED10 and T25, the lifetime cancer hazard after lifelong exposure to 1 microg acrylamide per kg body weight per day, scaled to humans, was calculated to be, on average, 1.3 x 10-3. Using this hazard level and correlating it with the exposure estimates, a lifetime cancer risk related to daily intake of acrylamide in foods for 70 years in males was calculated to be 0.6 x 10-3, implying that 6 out of 10,000 individuals may develop cancer due to acrylamide. For females, the risk values were slightly lower. It must be emphasized that this risk assessment is conservative. A number of processes may result in nonlinearity of the dose-response relationships for acrylamide carcinogenicity in the low-dose region, including detoxication reactions, cell cycle arrest, DNA repair, apoptosis, and immune surveillance. Thus, the true risk levels related to acrylamide intake may be considerably lower.
Authors:
E Dybing; T Sanner
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Publication Detail:
Type:  Journal Article     Date:  2003-06-12
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  75     ISSN:  1096-6080     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-08-02     Revised Date:  2010-09-17    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  IM    
Affiliation:
Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway. erik.dybing@fhi.no
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MeSH Terms
Descriptor/Qualifier:
Acrylamide / analysis,  toxicity*
Adolescent
Adult
Aged
Animals
Carcinogens / analysis,  toxicity*
Child
Female
Food Analysis
Food Contamination*
Humans
Male
Middle Aged
Neoplasms / chemically induced
Questionnaires
Rats
Risk Assessment
Water Pollutants, Chemical / analysis,  toxicity
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Water Pollutants, Chemical; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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