| Risk analyses for screening sigmoidoscopy based on a colorectal cancer (CRC) population. | |
| | |
MedLine Citation:
|
PMID: 18836946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Although colonoscopy can be effective in the prevention of colorectal cancer (CRC), it requires many endoscopic facilities, has a high patient burden and risk of complications, and it is expensive. The aim of this study was to determine the risk for proximal CRC and to identify subgroups in which screening sigmoidoscopy can be effective. MATERIAL AND METHODS: A database search was carried out on all patients who underwent endoscopy of the lower gastrointestinal (GI) tract between 1997 and 2005. All patients diagnosed with CRC were included. Variables including age, gender and the presence of distal colonic neoplasia were used for risk analyses. RESULTS: In total, 783 patients were diagnosed with CRC. Tumour was located in the proximal colon in 68/255 (27%) of the patients <65 years. Of the patients <65 years, 22% (57/255) had proximal CRC without synchronous distal lesions and would thus have been missed by sigmoidoscopy screening. Among patients >65 years, 41% (216/528) were diagnosed with proximal CRC, significantly more often in women than in men (p <0.001). In 35% of patients (185/528) proximal CRC without distal colonic neoplasia was found, significantly more than in those under 65 years of age (p <0.001). CONCLUSIONS: Significantly more proximal localized CRC would have been missed by sigmoidoscopy screening in elderly patients, especially in women. In subjects <65 years of age, sigmoidoscopy screening allows detection of almost 80% of CRC cases and might suffice as a screening method. |
| | |
Authors:
|
Sanna A Mulder; Rob J Th Ouwendijk; Raimond W Giard; Monique E Van Leerdam; Ernst J Kuipers |
Related Documents
:
|
1422716 - Safety of fibreoptic endoscopy: analysis of cardiorespiratory events. 19902866 - Osteonecrosis in inflammatory bowel diseases: a review of the literature. 15007306 - Fermentation of endogenous substrates is responsible for increased fasting breath hydro... 3676186 - Balance studies in patients with intestinal resection: how long is enough? 17547606 - Single chamber atrial pacing: a realistic option in sinus node disease: a long-term fol... 7234896 - Case report: comparative response of fever to corticosteroids in tuberculosis and in co... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 44 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-01-23 Completed Date: 2009-06-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
|
Languages: eng Pagination: 205-10 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, Ikazia Hospital, Rotterdam, The Netherlands. S.mulder.1@erasmusmc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Colorectal Neoplasms / diagnosis*, epidemiology*, pathology Female Humans Male Mass Screening Middle Aged Neoplasm Staging Prevalence Risk Assessment Risk Factors Sigmoidoscopy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age and stress related phenotypical changes in bone marrow CD34+ cells.
Next Document: Severe sepsis in autologous stem cell transplant recipients: microbiological aetiology, risk factors...