Document Detail

Risk of amputation following limb salvage surgery with endoprosthetic replacement, in a consecutive series of 1261 patients.
MedLine Citation:
PMID:  12799759     Owner:  NLM     Status:  MEDLINE    
Endoprosthetic replacements are commonly used for limb salvage following surgical excision of bone tumours. Advantages include initial reliability, rapid restoration of function and their ready availability. Potential long-term problems include loosening, infection and mechanical failure. Increasing problems may lead to the necessity for amputation; this paper assesses that risk. A total of 1,261 patients have undergone endoprosthetic replacements in our centre in the past 34 years, with a total of 6,507 patient years of follow up. A total of 112 patients have had subsequent amputation. The reasons for amputation were local recurrence in 71, infection in 38, mechanical failure in two and chronic pain in one. The proximal tibia had the greatest risk of amputation (n=38/245). The time to amputation varied from 2 days to 16 years, with a mean of 31 months. The risk of amputation decreased with time, although 10% took place after more than 5 years.
L M Jeys; R J Grimer; S R Carter; R M Tillman
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Publication Detail:
Type:  Journal Article     Date:  2003-02-08
Journal Detail:
Title:  International orthopaedics     Volume:  27     ISSN:  0341-2695     ISO Abbreviation:  Int Orthop     Publication Date:  2003  
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-11-05     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  160-3     Citation Subset:  IM    
Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham, B31 2AP United Kingdom.
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MeSH Terms
Amputation / adverse effects*,  methods
Bone Neoplasms / pathology,  surgery*
Cohort Studies
Follow-Up Studies
Limb Salvage / adverse effects,  methods*
Middle Aged
Neoplasm Staging
Postoperative Complications / epidemiology
Prosthesis Failure
Prosthesis Implantation / adverse effects
Risk Assessment
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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