Document Detail

Risk of adverse outcomes in pregnant women exposed to solvents.
MedLine Citation:
PMID:  9773364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare maternal and live birth outcomes of women who received consultation services between 1990 and 1993 from the Wisconsin occupational reproductive health nurse consultant (76% of whom were solvent-exposed) and a sample of women and their offspring selected randomly from birth certificate records drawn from the same years. DESIGN: Historical cohort study. SETTING: Consultations occurred primarily through telephone contacts with pregnant women workers in Wisconsin. Birth certificate records were used to obtain additional information. PARTICIPANTS: The convenience sample of largely solvent-exposed clients was compared with a random sample of women identified through birth records. MAIN OUTCOME MEASURES: Relative risk (RR) estimates. RESULTS: Confounding by race, prenatal care, and gestational diabetes was controlled by stratification. Logistic regression was used to control for age differences. Clients had elevated RR estimates for pregnancy-induced hypertension (RR = 2.4) and hydramnios (RR = 5.2), and their offspring were more likely to have 5-minute Apgar scores less than 8 (RR = 3.6). All other outcomes that were examined, including prematurity, low birth weight, and birth defects, were similar between groups. CONCLUSIONS: Most maternal and live birth outcomes were similar between the clients who sought consultation and the random sample of women. The current study supports previous research, which shows an elevated risk of pregnancy-induced hypertension associated with solvent exposure in women. The increased risk of hydramnios found in this largely solvent-exposed cohort was not found in the literature.
J B Hewitt; L Tellier
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG     Volume:  27     ISSN:  0884-2175     ISO Abbreviation:  J Obstet Gynecol Neonatal Nurs     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503123     Medline TA:  J Obstet Gynecol Neonatal Nurs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-31     Citation Subset:  IM; N    
Department of Health Restoration, University of Wisconsin-Milwaukee School of Nursing 53201, USA.
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MeSH Terms
Birth Weight
Cohort Studies
Hazardous Substances / adverse effects*
Infant, Newborn
Logistic Models
Maternal-Child Nursing*
Occupational Exposure / adverse effects*
Pregnancy Complications*
Pregnancy Outcome*
Solvents / adverse effects*
Reg. No./Substance:
0/Hazardous Substances; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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