Document Detail

Risk of advanced gastric precancerous lesions in Helicobacter pylori infected subjects is influenced by ABO blood group and cagA status.
MedLine Citation:
PMID:  23319424     Owner:  NLM     Status:  MEDLINE    
A higher incidence of stomach cancer in ABO blood type A individuals than in those with blood type O has been known for a long time. We studied this association in relation to Helicobacter pylori (Hp) of different cagA status. For our study, we used baseline gastric histopathology data and DNAs from frozen gastric biopsies of 2,077 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela. We analyzed six single nucleotide polymorphisms in the ABO gene, and we assessed the presence of the Hp cagA gene. Odds ratios (ORs) for risk of advanced precancerous gastric lesions were calculated using individuals with normal gastric epithelium or non-atrophic gastritis as a reference. Among individuals carrying a cagA negative Hp infection or no Hp infection, those with blood type A had a lower risk of intestinal metaplasia (IM) and dysplasia than those with blood type O (OR=0.60; 95% CI 0.38-0.94). In carriers of cagA positive Hp strains, individuals with blood type A had a higher risk of IM or dysplasia than those with blood type O (OR=1.42, 95% CI 1.09-1.86) and a higher risk if compared to subjects carrying cagA negative strain and non-A blood group (OR=3.82, 95% CI=2.80-5.20). The interaction between Hp cagA status and blood type was statistically significant (p=0.0006). We showed that SNPs in the ABO gene, predictive of ABO blood groups, are associated with risk of advanced precancerous gastric lesions in individuals infected with Hp, but the assessment of the risk is strictly dependent on cagA status.
Cosmeri Rizzato; Ikuko Kato; Martyn Plummer; Nubia Muñoz; Angelika Stein; Leen Jan van Doorn; Silvia Franceschi; Federico Canzian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-12
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  133     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2013-07-11     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 UICC.
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MeSH Terms
ABO Blood-Group System / genetics*
Anticarcinogenic Agents / pharmacology
Antigens, Bacterial / metabolism*
Bacterial Proteins / metabolism*
Helicobacter Infections / microbiology*
Helicobacter pylori / metabolism*
Metaplasia / pathology
Middle Aged
Polymorphism, Single Nucleotide
Precancerous Conditions / microbiology*
Randomized Controlled Trials as Topic
Risk Factors
Stomach Neoplasms / microbiology*
Grant Support
Reg. No./Substance:
0/ABO Blood-Group System; 0/Anticarcinogenic Agents; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/cagA protein, Helicobacter pylori

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