| Risk of acute renal failure in patients with Type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 22017349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: Progressive decline in renal function has been well-described in patients with Type 2 diabetes mellitus, but few studies have assessed the risk of acute renal failure in a large population of patients with Type 2 diabetes. This study quantified the risk of acute renal failure associated with Type 2 diabetes in the General Practice Research Database from the UK. Methods: Patients with Type 2 diabetes (n = 119 966) and patients without diabetes (n = 1 794 516) were identified in the General Practice Research Database. Patients with end-stage renal disease were excluded. Crude incidence and multivariate-adjusted hazard ratios of acute renal failure were estimated for patients with Type 2 diabetes relative to those without diabetes. Cox regression models were adjusted for a variety of co-morbidities. Increase of acute renal failure risk resulting from additive effects of specific co-morbidities with Type 2 diabetes was also assessed. Results: Between 2003 and 2007, acute renal failure incidence was 198 per 100 000 person-years in patients with Type 2 diabetes compared with 27 per 100 000 patients-years among patients without Type 2 diabetes (crude hazard ratio 8.0, 95% CI 7.4-8.7). Risk of acute renal failure for patients with Type 2 diabetes remained significant, but was attenuated in multivariate analyses adjusting for various co-morbidities (adjusted hazard ratio 2.5, 95% CI 2.2-2.7). Age and specific co-morbidities (chronic kidney disease, hypertension and congestive heart failure) were also associated with increased risk of acute renal failure in Type 2 diabetes. Conclusions: Patients with Type 2 diabetes have increased risk for acute renal failure compared with patients without diabetes, even after adjustment for known risk factors, particularly in the elderly and those with other co-morbidities such as chronic kidney disease, congestive heart failure and hypertension. |
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Authors:
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C J Girman; T D Kou; K Brodovicz; C M Alexander; E A O'Neill; S Engel; D E Williams-Herman; L Katz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Journal compilation © 2011 Diabetes UK. |
Affiliation:
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Merck Sharp & Dohme Corp., Whitehouse Station, NJ Amgen Inc., Thousand Oaks, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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