Document Detail

Risk of Overestimation of Kidney Function Using GFR-Estimating Equations in Patients with Low Inulin Clearance.
MedLine Citation:
PMID:  22811357     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Accurate estimation of the glomerular filtration rate (GFR) is very important in clinical practice. Although renal inulin clearance (Cin) is the gold standard for measuring GFR, the procedure for Cin measurement is complicated. Use of GFR-estimating equations has been increasing recently due to their simplicity. The objectives of the present study are to analyze the correlation between Cin and other GFR-estimating parameters and to investigate their clinical usefulness and limitation.
METHODS: Seventy-two Japanese patients were enrolled in this study. Cin was measured by the continuous infusion method. Serum creatinine (s-Cr), cystatin C, uric acid (UA), and hemoglobin (Hb) were measured. The Japanese formula of estimated GFR (eGFR) was as follows: eGFR (ml/min/1.73m(2) ) = 194 × s-Cr(-1.094) × Age(-0.287) × 0.739 (if female). The endogenous creatinine clearance test was also performed.
RESULTS: Levels of Cin were highly correlated with those of endogenous creatinine clearance (Ccr) (R(2) = 0.7585) and eGFR (R(2) = 0.5659). However, patients with lower Cin showed unexpectedly elevated levels of endogenous Ccr and eGFR. Moreover, the levels of eGFR tended to be unexpectedly increased in patients with low body surface area.
CONCLUSION: Although GFR-estimating equations are useful for estimating GFR accurately, they pose a risk of overestimation of kidney function in patients with decreased GFRor a poor physique. J. Clin. Lab. Anal. 26:248-253, 2012. © 2012 Wiley Periodicals, Inc.
Junichiro Nakata; Isao Ohsawa; Kisara Onda; Mitsuo Tanimoto; Gaku Kusaba; Yukihiko Takeda; Noriyoshi Kobayashi; Katsuhiko Asanuma; Yuichi Tanaka; Michiko Sato; Yuko Inami; Hitoshi Suzuki; Hiyori Suzuki; Atsumi Masuda; Kanae Nonaka; Yu Sasaki; Atsuko Hisada; Chieko Hamada; Satoshi Horikoshi; Yasuhiko Tomino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  26     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-53     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
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