| Risk of Long-Term Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantation in Octogenarians. | |
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MedLine Citation:
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PMID: 23379754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the risk of long-term dual antiplatelet therapy (DAT) following drug-eluting stent (DES) implantation in octogenarians. BACKGROUND: DES implantation requires DAT; however, DAT-associated risk in octogenarians remains unclear. METHODS: Two-hundred and six consecutive octogenarians (130 men, 83.3 ± 3.4 years) underwent stent implantation (104 bare metal stents [BMSs] and 102 DESs) and 38.0 ± 13.2 months of follow-up. RESULTS: Significantly more DES patients received DAT. The incidence of bleeding events was similar in the DES and BMS groups for 1 year (total: 10.8% vs 5.8%, P = 0.19; major: 4.9% vs 2.9%, P = 0.70). However, after 2 years, significantly more bleeding events occurred in the DES group than the BMS group (total: 2 years, 21.6% vs 9.6%, P = 0.02; 3 years, 29.4% vs 11.5%, P = 0.001; 4 years, 31.4% vs 15.4%, P = 0.007; major: 2 years, 12.7% vs 3.8%, P = 0.04; 3 years, 18.6% vs 5.8%, P = 0.005; 4 years, 19.6% vs 6.7%, P = 0.006). Overall, significantly more total bleeding events (31.4% vs 15.4%, P = 0.007) and major bleeding events (19.2% vs 6.7%, P = 0.006) were observed in the DES group than in the BMS group. The adjusted hazard ratios and 95% confidence intervals (CI) were as follows: total bleeding events, 2.203 (95% CI: 1.065-4.556; P = 0.033); major bleeding events, 4.324 (1.506-12.414; P = 0.007). CONCLUSIONS: DAT was associated with an increased risk of bleeding events in octogenarians after 2 years. DAT discontinuation should be considered for octogenarians 1-year post-DES implantation. |
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Authors:
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Junya Matsumi; Satoshi Takeshita; Koki Shishido; Kazuya Sugitatsu; Shingo Mizuno; Hidetaka Suenaga; Yutaka Tanaka; Saeko Takahashi; Shigeru Saito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-5 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: - ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013, Wiley Periodicals, Inc. |
Affiliation:
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Department of Cardiology and Catheterization Laboratory, and Cardiovascular R&D Center, Shonan Kamakura General Hospital, Kamakura, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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