Document Detail


Risk of injury due to alcohol: evaluating potential bias using the case-crossover usual-frequency method.
MedLine Citation:
PMID:  23348068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The usual-frequency case-crossover method, comparing exposure before an event with typical exposure of the same person, is widely used to estimate the risk of injury related to acute alcohol use. Prior results suggest that risk estimates might be biased upward compared with other methods.
METHODS: Using data from 15 emergency room studies in seven countries, we compared the usual-frequency case-crossover method with case-control analysis, using noninjury patients as controls. Control-crossover analysis was performed to examine potential bias and to adjust risk estimates.
RESULTS: The cross-study pooled odds ratio (OR) of injury related to drinking was 4.7 (95% confidence interval = 2.6-8.5) in case-crossover analysis and 2.1 (1.6-2.7) in case-control analysis. A control-crossover analysis found an indication of bias (OR = 2.2 [1.8-2.8]), which was larger among less-frequent drinkers.
CONCLUSION: Findings suggest that the potential overestimation of injury risk based on the usual-frequency case-crossover method might be best explained by recall bias in usual-frequency estimates.
Authors:
Yu Ye; Jason Bond; Cheryl J Cherpitel; Tim Stockwell; Scott Macdonald; Jürgen Rehm
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  24     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-23     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / adverse effects*,  epidemiology
Bias (Epidemiology)*
Case-Control Studies*
Cross-Over Studies*
Emergency Service, Hospital
Humans
Logistic Models
Odds Ratio
Risk
Wounds and Injuries / epidemiology
Grant Support
ID/Acronym/Agency:
P50 AA005595/AA/NIAAA NIH HHS; P50 AA005595/AA/NIAAA NIH HHS; R01 AA013750/AA/NIAAA NIH HHS; R01 AA013750/AA/NIAAA NIH HHS
Comments/Corrections

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