Document Detail

Risk indicators for eclampsia in gestational hypertension or mild preeclampsia at term.
MedLine Citation:
PMID:  20822426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether eclampsia can be predicted in gestational hypertension or mild preeclampsia at term.
METHODS: For this case-control study we selected 76 cases with eclampsia from the LEMMoN study and 1149 controls with mild hypertensive disease of pregnancy, who did not develop eclampsia, from the HYPITAT study. Risk indicators for eclampsia, identified in multivariable logistic regression, were used to assess the predictive capacity of our model with receiver-operating characteristic (ROC) curve analysis. Model optimism was assessed with bootstrapping.
RESULTS: Maternal age, non-Caucasian ethnicity, systolic blood pressure >155 mmHg, ≥2+ protein on dipstick, elevated uric acid, creatinin >74 μmol/L, aspartate aminotransferase >30 U/L, and lactate dehydrogenase >400 U/L were significantly associated with eclampsia. Other factors included in the model were previous fetal loss, previous miscarriage, gestational age, and low platelet count. The area under the ROC curve was 0.92. Bootstrapping showed minimal overfitting of the model.
CONCLUSION: In women with gestational hypertension or mild preeclampsia at term eclampsia can be predicted.
Corine M Koopmans; Joost J Zwart; Henk Groen; Kitty W M Bloemenkamp; Ben W J Mol; Maria G Van Pampus; Jos Van Roosmalen
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-07
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-30     Completed Date:  2012-01-19     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-46     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Eclampsia / diagnosis,  epidemiology,  etiology
Hypertension, Pregnancy-Induced / diagnosis*,  epidemiology*,  etiology
Netherlands / epidemiology
Pre-Eclampsia / diagnosis,  epidemiology,  etiology
Predictive Value of Tests
Pregnancy Trimester, Third
Prenatal Diagnosis*
ROC Curve
Risk Factors
Severity of Illness Index
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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