Document Detail

Risk of hypertension among young adults who were born preterm: a Swedish national study of 636,000 births.
MedLine Citation:
PMID:  21320866     Owner:  NLM     Status:  MEDLINE    
Previous studies have reported an association between preterm birth and elevated blood pressure in adolescence and young adulthood. These studies were based on single-day blood pressure measurements and had limited ability to estimate risk of hypertension measured over a longer period and across the full range of gestational ages. The authors conducted a national cohort study of all infants born in Sweden from 1973 through 1979 (n = 636,552), including 28,220 born preterm (<37 weeks), followed to ages 25.5-37.0 years to determine whether individuals born preterm were more likely to be prescribed antihypertensive medications in 2005-2009 than those born full term. Antihypertensive medication data were obtained from all outpatient and inpatient pharmacies throughout Sweden. Young adults who were born preterm had an increased relative rate of antihypertensive medication prescription that increased monotonically by earlier gestational age and that was independent of fetal growth. The adjusted odds ratio for ≥1 antihypertensive medications/year ranged from 1.25 (95% confidence interval: 1.12, 1.39) for those born near term (35-36 weeks) to 2.51 (95% confidence interval: 1.11, 5.68) for those born extremely preterm (23-27 weeks) relative to those born full term. These findings suggest that preterm birth is strongly associated with hypertension in young adulthood, including an increased risk among those born near term.
Casey Crump; Marilyn A Winkleby; Kristina Sundquist; Jan Sundquist
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-13
Journal Detail:
Title:  American journal of epidemiology     Volume:  173     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-05     Completed Date:  2011-06-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  797-803     Citation Subset:  IM    
Stanford Family Medicine, 211 Quarry Road, Palo Alto, CA 94304-5765, USA.
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MeSH Terms
Antihypertensive Agents / administration & dosage*
Confidence Intervals
Hypertension / drug therapy*,  epidemiology*
Logistic Models
Middle Aged
Physician's Practice Patterns / statistics & numerical data*
Population Surveillance
Premature Birth*
Risk Factors
Sweden / epidemiology
Grant Support
1R01HD052848-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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