Document Detail


Risk Factors for Severe Retinopathy of Prematurity in Preterm Low Birth Weight Neonates.
MedLine Citation:
PMID:  21340729     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the risk factors predisposing to severe retinopathy of prematurity (ROP) in a level III neonatal unit. This retrospective study was conducted in a tertiary care neonatal and ophthalmic center. METHODS: The authors retrospectively analyzed data of preterm infants who were born from January 2003 through December 2008 and were screened for ROP. Data were collected from prospectively filled ROP screening forms. All the neonates with gestation ≤ 32 wks or birth weight ≤1500 g were screened. In addition, infants with birth weight of 1501-1800 g or gestation of 33-34 wks were also screened in the presence of additional risk factors like need for oxygen or mechanical ventilation. Primary outcome was severe ROP defined as treatable ROP as per type I ETROP guidelines (after year 2005) or threshold disease (before 2005). RESULTS: A total of 704 neonates were screened during the study period, of whom 84 (11.9%) and 33 (4.7%) infants developed any ROP and severe ROP, respectively. The mean birth weight and gestation of infants with severe ROP were 1113 ±438 g and 29 ± 3 wks, respectively. The following risk factors were found to be significant for severe ROP on univariate analysis: gestation ≤ 30 wks, birth weight <1000 g, respiratory distress syndrome, use of surfactant, apnea, hypotension, patent ductus arteriosus (PDA), sepsis, necrotizing enterocolitis, pneumonia, meningitis, intraventricular hemorrhage, packed cell transfusion, and use of oxygen, continuous positive airway pressure and positive pressure ventilation. On multivariate analysis by stepwise logistic regression, respiratory distress syndrome (adjusted OR: 8.1 (95% CI 2.6-25.1); p < 0.001), PDA requiring medical or surgical management (adjusted OR: 3.2 (95% CI 1.1-8.9); p = 0.03), and meningitis (adjusted OR: 6.7 (95% CI 1.9-23.0); p = 0.002) were found to be independently associated with severe ROP. All infants with severe ROP had regression of the disease after laser therapy. CONCLUSIONS: Respiratory distress syndrome, PDA requiring medical or surgical management and meningitis were found to be associated with severe ROP. Outcomes were good after laser therapy with all followed-up infants having regression of the disease.
Authors:
Pardeep Kumar; M Jeeva Sankar; Ashok Deorari; Rajvardhan Azad; Parijat Chandra; Ramesh Agarwal; Vinod Paul
Related Documents :
21699999 - A neonatal mouse model of intermittent hypoxia associated with features of apnea in pre...
12521409 - Primary postpartum haemorrhage.
21284459 - Analysis of the risk of shunt failure or infection related to cerebrospinal fluid cell ...
19766979 - Maternal activity restriction and the prevention of preterm birth.
21366129 - Racial and ethnic disparity in male preterm singleton birth.
6997179 - Glucocorticoids in prevention of respiratory distress syndrome.
10727809 - Polycyclic diterpenoids from euphorbia characias.
6147559 - Infants in juba, southern sudan: the first twelve months of life.
8170489 - Electromyography and biopsy correlation with suggested protocol for evaluation of the f...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-22
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  -     ISSN:  0973-7693     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bacterial Profile of the Oropharynx in Infants: An Assessment of the Confounding Factors for Coloniz...
Next Document:  Laparoscopic Heller myotomy plus Dor fundoplication in 137 achalasic patients: results on symptoms r...