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Risk factors for recurrent lumbar disc herniations.
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PMID:  24761206     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The most common complication after lumbar discectomy is reherniation. As the first step in reducing the rate of recurrence, many studies have been conducted to find out the factors that may increase the reherniation risk. Some reported factors are age, sex, the type of lumbar disc herniation, the amount of fragments removed, smoking, alcohol consumption and the length of restricted activities. In this review, the factors studied thus far are summarized, excepting factors which cannot be chosen or changed, such as age or sex. Apart from the factors shown here, many other risk factors such as diabetes, family history, history of external injury, duration of illness and body mass index are considered. Few are agreed upon by all. The reason for the diverse opinions may be that many clinical and biomechanical variables are involved in the prognosis following operation. For the investigation of risk factors in recurrent lumbar disc herniation, large-scale multicenter prospective studies will be required in the future.
Authors:
Byung-Joon Shin
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Publication Detail:
Type:  Journal Article; Review     Date:  2014-04-08
Journal Detail:
Title:  Asian spine journal     Volume:  8     ISSN:  1976-1902     ISO Abbreviation:  Asian Spine J     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-24     Completed Date:  2014-06-24     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101314177     Medline TA:  Asian Spine J     Country:  Korea (South)    
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Languages:  eng     Pagination:  211-5     Citation Subset:  -    
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Journal Information
Journal ID (nlm-ta): Asian Spine J
Journal ID (iso-abbrev): Asian Spine J
Journal ID (publisher-id): ASJ
ISSN: 1976-1902
ISSN: 1976-7846
Publisher: Korean Society of Spine Surgery
Article Information
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Copyright © 2014 by Korean Society of Spine Surgery
open-access:
Received Day: 03 Month: 2 Year: 2014
Revision Received Day: 03 Month: 2 Year: 2014
Accepted Day: 04 Month: 2 Year: 2014
Print publication date: Month: 4 Year: 2014
Electronic publication date: Day: 08 Month: 4 Year: 2014
Volume: 8 Issue: 2
First Page: 211 Last Page: 215
PubMed Id: 24761206
ID: 3996348
DOI: 10.4184/asj.2014.8.2.211

Risk Factors for Recurrent Lumbar Disc Herniations
Byung-Joon ShinA1
Department of Orthopaedic Surgery, Spine Center, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
Correspondence: Corresponding author: Byung-Joon Shin. Department of Orthopaedic Surgery, Spine Center, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul 140-743, Korea. Tel: 82-2-709-9051, Fax: +82-2-796-3682, schsbj@schmc.ac.kr

Introduction

Since the publication of a seminal paper eighty years ago by Mixter and Barr [1], "Rupture of the Intervertebral Disk with Involvement of Spinal Canal," lumbar discectomy has become one of the most common spinal surgeries around the globe. There are approximately 90,000 cases of lumbar discectomy conducted each year in Korea.

With the increased number of herniated lumbar disc cases, there has been prolific research on the subject, with diagnosis and treatment modalities improved and diversified over the past few decades. Herniated lumbar disc can be improved by conservative treatment, and only ten percent of all lumbar disc herniation cases are candidates for surgery. If cauda equina syndrome is developed or if there is no pain relief after six weeks of nonsurgical treatment, surgery becomes a reasonable option. Even with a long duration of illness, if the patient complains only of back pain and radiating pain without neurological deficits, a prolonged nonsurgical care may be recommended. The outcome of surgical treatment is encouraging, as 80% to 90% of cases show successful results.

However, most patients with lumbar disc herniation have negative perceptions of the surgical treatment, with the primary concern being the "fear of recurrence." Possible complications of lumbar discectomy are hematoma, infection, dural injury and nerve root injury among others. Recurrence and reoperation are the most frequently reported, and thus the patients' anxiety is well-founded.

There are many studies on recurrent lumbar disc herniation, but there is no clear definition of a "recurrence." According to Swartz and Trost [2], reherniation is the experience of another lumbar disc herniation more than six months after the index operation, at either ipsilateral or contralateral location. Clinically speaking, herniation at the same level and same side would be more appropriate for recurrence. However, it is not necessary to confine the time without pain to six months. If the symptom returns after a pain-free period, it can be defined as recurrence. As such, the cases with persistent symptoms after surgery and the cases with symptoms disappearing for some time, regardless of the length of pain-free period, should be categorized differently.

The recurrence rate after lumbar discectomy is reported at 1% to 21% [3,4], showing a significant range, with many studies on the risk factors causing recurrent herniated lumbar disc. Some of the most often mentioned risk factors for recurrence are age at the time of surgery, sex, herniation type, the amount of removed lumbar disc material, alcohol consumption and the start of exercise. Aside from these, there have been many other factors raised. We here focus on the factors excepting the unchangeable factors, such as age and sex.


Herniation Type

Carragee et al. [5] conducted a prospective study on the recurrence rate after lumbar disc herniation in 187 patients, who had microdiscectomy due to monosegmental lumbar disc herniation. The study showed the reherniation and reoperation rate at 9% and 6%, respectively.

The herniation type was categorized into four groups, with the recurrence rate investigated. The classification is as follows: 1) Type I, fragment-fissure herniation; 2) Type II, fragment-defect herniation; 3) Type III, fragment-contained herniation; and 4) Type IV, non-fragment-contained herniation.

It was found that type II (fragment-defect herniation group), with extruded fragment and massive defect on the posterior annulus, showed 27% chance of recurrence and 21% chance of reoperation. Type IV (non-fragment-contained group) showed 38% chance of remaining radiating pain and recurrence. This result has often been referred to as evidence of close correlation between lumbar disc herniation type and reherniation. It is generally known that the surgery of sequestrated type brings superior results to that of extruded type or contained type [6], with sequestrated type being similar to fragment-fissure type. Carragee et al.'s report [5] shows that the recurrent rate of fragment-fissure type is as low as 1%, which coincides with the fact that surgery is most successful in the sequestrated type. In this article, Carragee et al. [5] noted that all patients were treated with limited discectomy (LD) only. The corresponding criticism was that the reason for the high recurrence rate in fragment-defect group with massive defect at annulus was their not having undergone subtotal discectomy (SD), which removes much of lumbar disc material aggressively. Carragee's study in the next section answers this question, showing the clinical outcomes of treatment not targeting all types of lumbar herniated discs, but treating only type II fragment-defect group, either with SD or LD.

After comparing the recurrence rate of three different types of herniation (protruded, extruded, sequestrated), Miwa et al. [7] reported that the sequestrated type showed 15.4%, which was much higher than the rates of other types, which ranged from 7% to 10%.


SD versus LD

There are two techniques that are often used in open discectomy. SD or aggressive discectomy [8] removes as much of herniated fragments as possible, along with curettage in lumbar disc. The second technique, known as LD or conservative discectomy [9,10], removes only the extruded or loose intradiscal fragments and saves other parts within the disc space. The former technique (SD), which focuses on removing as much of disc material as possible to decrease the risk of reherniation, can accelerate degenerative change of intervertebral disc, by a possible injury to end plate during the surgery. An increased chance of disc space narrowing and back pain may be disadvantages of this procedure. The latter technique can produce less perineural scar and preserve disc space height. However, some fragments may be remained after operation, presenting the cause for recurrence [11].

A prospective observational study compared the clinical outcomes of two different discectomy techniques. The reherniation rate in the LD group was 18%, while that of the SD group was 9% at follow-up; and the reoperation rate was 10% versus 7%, respectively [12]. Despite the tendency toward a higher recurrence rate after LD, clinical outcomes and patient satisfaction at 1-year and 2-year follow-up were higher in the LD group.

Having conducted prospective randomized study with 40 cases of LD group and 38 cases of SD group, Barth et al. [13] observed that LD group showed statistically better results in terms of back pain and clinical outcomes at 2-year follow-up. However, recurrence rate was 12.5% in LD and 10.5% in SD, showing there was no significant difference between the two groups. Many other retrospective studies have compared the two techniques to diverse results, with LD being associated with lower recurrence rate [14] to LD causing dominantly higher rate of recurrence (21% in LD vs. 0% in SD) [4]. These retrospective studies have less power as evidence than prospective and randomized studies.

McGirt et al. [15] carried out a meta-analysis of 54 studies, which included 13,359 cases of lumbar discectomy for the two methods. It revealed that immediately after surgery, the frequency of back pain and radiculopathy were similar in the two groups, but in two years or more, the frequency was 2.5 times higher in SD (mean, 11.6% in LD vs. 27.8% in SD). On the contrary, the frequency of recurrent disc herniation was higher in LD group (mean, 7% vs. 3.5%).

The controversy surrounding the two surgical techniques continues. Wera et al. [3] informed that the rate of reherniation within one year in 1,320 events of SD was only 1%, and that there was no difference with LD in terms of frequency of back pain after surgery. In considering that the most critical factor in anticipating clinical results of lumbar discectomy is "no reherniation," Wera et al. [3] pointed out that in Carragee's report, the recurrence rate was higher and the total number of patients included for the study was only 76 cases (SD, 30; LD, 46). It raised a question on the conclusion that clinical outcomes and patient satisfaction at 1-year and 2-year follow-up were higher in LD group. Therefore, as McGirt et al. [15] suggested, well-designed prospective randomized trials are required in order to see more precisely the difference between the two techniques.


Smoking

Smoking has been proven not only to trigger lung diseases but also to accelerate disc degeneration and back pain [16,17]. Moreover, there is a report that smoking is an important risk factor for recurrent disc herniation [7,18]. After having analyzed 32 reoperation cases out of 298 primary discectomy cases, Miwa et al. [7] revealed that the group of patients who was smoking at the time of surgery showed 18.5% of recurrence rate, which was much higher than the recurrence rate of non-smokers (odds ratio, 3.472; 95% confidence interval, 1.547-7.795; p=0.003).

With smoking, more than 4,000 substances can be absorbed into our body, including nicotine, carbon monoxide and hydrogen cyanide, which are known to affect cellular multiplication, blood oxygenation and tissue perfusion. Lumbar discs are the biggest avascular structures in human body, and receive all nutrients from the blood by diffusion. Nutrients diffuse from the capillaries that are originated from vertebral vasculatures and go through subchondral bone, reaching bone-disc junction [19,20].

It has been shown in animal experiments that smoking contracts capillary vessels that are dispersed up to bone-disc junction, and deteriorate solute transport into the disc dramatically [21]. Moreover, nicotine interrupts multiplication of nucleus pulposus cells, causing decrease in the number of cells, and disturbs the synthesis of extracellular matrix, causing disruption of intercellular architectures. These mechanisms are likely to be related to the pathogenesis of disc degeneration [22]. Through the same mechanism of action, nicotine delays the healing process of tissues, such as skin, bone and ligament [23,24,25,26,27]. Miwa et al. [7] supposed that smoking also affects healing of annulus or posterior longitudinal ligament after lumbar discectomy and increases the rate of recurrence.


Activity Restriction

How long should patients limit their activities? Taking into account that the primary goal of any type of treatment is to help patients regain the functions of health condition, it would be good to allow them to return to normal level of daily activities as soon as possible. However, it is not a clinically easy decision to allow the patients to start full range of activities, as they have serious anxiety and suspicion on the risk of recurrence. Following lumbar discectomy, walking is usually allowed on the same day of surgery or the next day, going back to office work within 2 to 3 weeks and returning to manual work 6 to 8 weeks after the surgery [28]. However, some patients have been shown to return to work within 1 to 2 weeks following surgery and to adjust themselves well without problems. Especially when the patient is a doctor, he or she is often back to work such as outpatient clinic or operation theatre for patient care within 2 or 3 days after surgery. While there has been no research on whether reherniation is more likely to happen in the early return-to-work patients or not, if early full activities do not influence negatively on prognosis, patients should be allowed to return to the normal level of activities as deemed suitable.

Carragee et al. [29], having this point in mind, held a prospective study in which they observed 152 limited lumbar discectomy patients without any activity restrictions after discectomy. Study results showed that, apart from three patients who were not able to return to work eventually, 149 people returned to work in 1.2 weeks on average, and they performed full duty within 2.2 weeks. Nine patients (6%) changed jobs due to back pain and radiculopathy, and eight patients (5.3%) needed reoperation. These are not inferior results as compared to generally reported reoperation rate.

Not more than forty years ago, the pelvic traction was used to treat patients with herniated discs, which involved strapping the patient to a hospital bed for many weeks. Found to weaken the core muscles, the device is no longer used. We can forecast that the duration of activity restriction following discectomy procedure may get shorter in the future.


Conclusions

Some of the risk factors that contribute to lumbar disc reherniations after discectomy were here overviewed, with no exact factors that all agreed on. The diverse opinions may stem from the many clinical and biomechanical variables involved in the prognosis after operation. For spine surgeons performing the discectomies, it will be meaningful to see the types of research carried out and the current trends with regard to the various factors. The past reports and literatures will be useful in making a research plan to study the factors that increase the chance of developing a lumbar disc recurrence. It may be disappointing that there are no set answers, but it also follows that there is much to research.


Notes

No potential conflict of interest relevant to this article was reported.

References
1. Mixter WJ,Barr JS. Rupture of the intervertebral disc with involvement of the spinal canalN Engl J MedYear: 1934211210215
2. Swartz KR,Trost GR. Recurrent lumbar disc herniationNeurosurg FocusYear: 200315E1015347228
3. Wera GD,Marcus RE,Ghanayem AJ,Bohlman HH. Failure within one year following subtotal lumbar discectomyJ Bone Joint Surg AmYear: 200890101518171952
4. Rogers LA. Experience with limited versus extensive disc removal in patients undergoing microsurgical operations for ruptured lumbar discsNeurosurgeryYear: 19882282853344091
5. Carragee EJ,Han MY,Suen PW,Kim D. Clinical outcomes after lumbar discectomy for sciatica: the effects of fragment type and anular competenceJ Bone Joint Surg AmYear: 20038510210812533579
6. Dewing CB,Provencher MT,Riffenburgh RH,Kerr S,Manos RE. The outcomes of lumbar microdiscectomy in a young, active population: correlation by herniation type and levelSpine (Phila Pa 1976)Year: 200833333818165746
7. Miwa S,Yokogawa A,Kobayashi T,et al. Risk factors of recurrent lumbar disc herniation: a single center study and review of the literatureJ Spinal Disord TechYear: 2013Month: 11 Day: 08 [Epub]. http://dx.doi.org/10.1097/BSD.0b013e31828215b3.
8. O'Connell JE. Protrusions of the lumbar intervertebral discs, a clinical review based on five hundred cases treated by excision of the protrusionJ Bone Joint Surg BrYear: 19513383014814156
9. Williams RW. Microlumbar discectomy: a conservative surgical approach to the virgin herniated lumbar discSpine (Phila Pa 1976)Year: 19783175182663769
10. Spengler DM. Lumbar discectomy. Results with limited disc excision and selective foraminotomySpine (Phila Pa 1976)Year: 198276046077167834
11. Ebeling U,Kalbarcyk H,Reulen HJ. Microsurgical reoperation following lumbar disc surgery. Timing, surgical findings, and outcome in 92 patientsJ NeurosurgYear: 1989703974042915246
12. Carragee EJ,Spinnickie AO,Alamin TF,Paragioudakis S. A prospective controlled study of limited versus subtotal posterior discectomy: short-term outcomes in patients with herniated lumbar intervertebral discs and large posterior anular defectSpine (Phila Pa 1976)Year: 20063165365716540869
13. Barth M,Weiss C,Thome C. Two-year outcome after lumbar microdiscectomy versus microscopic sequestrectomy: part 1: evaluation of clinical outcomeSpine (Phila Pa 1976)Year: 20083326527218303458
14. Faulhauer K,Manicke C. Fragment excision versus conventional disc removal in the microsurgical treatment of herniated lumbar discActa Neurochir (Wien)Year: 19951331071118748751
15. McGirt MJ,Ambrossi GL,Datoo G,et al. Recurrent disc herniation and long-term back pain after primary lumbar discectomy: review of outcomes reported for limited versus aggressive disc removalNeurosurgeryYear: 20096433834419190461
16. An HS,Silveri CP,Simpson JM,et al. Comparison of smoking habits between patients with surgically confirmed herniated lumbar and cervical disc disease and controlsJ Spinal DisordYear: 199473693737819635
17. Kelsey JL,Githens PB,O'Conner T,et al. Acute prolapsed lumbar intervertebral disc. An epidemiologic study with special reference to driving automobiles and cigarette smokingSpine (Phila Pa 1976)Year: 198496086136495031
18. Shimia M,Babaei-Ghazani A,Sadat BE,Habibi B,Habibzadeh A. Risk factors of recurrent lumbar disk herniationAsian J NeurosurgYear: 20138939624049552
19. Urban JP,Smith S,Fairbank JC. Nutrition of the intervertebral discSpine (Phila Pa 1976)Year: 2004292700270915564919
20. Grunhagen T,Wilde G,Soukane DM,Shirazi-Adl SA,Urban JP. Nutrient supply and intervertebral disc metabolismJ Bone Joint Surg AmYear: 200688Suppl 2303516595440
21. Holm S,Nachemson A. Nutrition of the intervertebral disc: acute effects of cigarette smoking. An experimental animal studyUps J Med SciYear: 19889391993376356
22. Akmal M,Kesani A,Anand B,Singh A,Wiseman M,Goodship A. Effect of nicotine on spinal disc cells: a cellular mechanism for disc degenerationSpine (Phila Pa 1976)Year: 20042956857515129075
23. Kuri M,Nakagawa M,Tanaka H,Hasuo S,Kishi Y. Determination of the duration of preoperative smoking cessation to improve wound healing after head and neck surgeryAnesthesiologyYear: 200510289289615851873
24. Little CP,Burston BJ,Hopkinson-Woolley J,Burge P. Failure of surgery for scaphoid non-union is associated with smokingJ Hand Surg BrYear: 20063125225516488521
25. Sorensen LT,Karlsmark T,Gottrup F. Abstinence from smoking reduces incisional wound infection: a randomized controlled trialAnn SurgYear: 20032381512832959
26. Schmitz MA,Finnegan M,Natarajan R,Champine J. Effect of smoking on tibial shaft fracture healingClin Orthop Relat ResYear: 199936518420010627703
27. Moller AM,Pedersen T,Villebro N,Munksgaard A. Effect of smoking on early complications after elective orthopaedic surgeryJ Bone Joint Surg BrYear: 20038517818112678348
28. Cinotti G,Roysam GS,Eisenstein SM,Postacchini F. Ipsilateral recurrent lumbar disc herniation. A prospective, controlled studyJ Bone Joint Surg BrYear: 1998808258329768893
29. Carragee EJ,Han MY,Yang B,Kim DH,Kraemer H,Billys J. Activity restrictions after posterior lumbar discectomy. A prospective study of outcomes in 152 cases with no postoperative restrictionsSpine (Phila Pa 1976)Year: 1999242346235110586459

Article Categories:
  • Review Article

Keywords: Herniated disc, Lumbar region, Recurrence, Risk factors.

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