Document Detail


Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants.
MedLine Citation:
PMID:  22325187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants.
STUDY DESIGN: This is a retrospective analysis of ELBW (<1000 g) and <27 weeks' gestational age infants born in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network sites between January 2000 and June 2007. Infants were tracked until death or 18 to 22 months' corrected age. Infants who died between NICU discharge and the 18- to 22-month follow-up visit were classified as post-NICU discharge mortality (P-NDM). Association of maternal and infant risk factors with P-NDM was determined using logistic regression analysis. A prediction model with 6 significant predictors was developed and validated.
RESULTS: There were 5364 infants who survived to NICU discharge; 557 (10%) infants were lost to follow-up, and 107 infants died following NICU discharge. P-NDM rate was 22.3 per 1000 ELBW infants. In the prediction model, African American race, unknown maternal health insurance, and hospital stay ≥ 120 days significantly increased risk, and maternal exposure to intrapartum antibiotics was associated with decreased risk of P-NDM.
CONCLUSION: We identified African American race, unknown medical insurance, and prolonged NICU stay as risk factors associated with P-NDM among ELBW infants.
Authors:
Lilia C De Jesus; Athina Pappas; Seetha Shankaran; Douglas Kendrick; Abhik Das; Rosemary D Higgins; Edward F Bell; Barbara J Stoll; Abbot R Laptook; Michele C Walsh;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-10
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-09-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-4.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Wayne State University, Detroit, MI, USA.
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Female
Humans
Infant Mortality*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Intensive Care Units, Neonatal*
Male
Patient Discharge*
Retrospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
(U10 HD36790/HD/NICHD NIH HHS; M01 RR125/RR/NCRR NIH HHS; M01 RR16587/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR54/RR/NCRR NIH HHS; M01 RR59/RR/NCRR NIH HHS; M01 RR6022/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR64/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; M01 RR997/RR/NCRR NIH HHS; NCRR UL1 024160//PHS HHS; U10 HD021385-26/HD/NICHD NIH HHS; U10 HD053089/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21415/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27881/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; U10 HD53089/HD/NICHD NIH HHS; U10 HD53109/HD/NICHD NIH HHS; U10 HD53119/HD/NICHD NIH HHS; U10 HD53124/HD/NICHD NIH HHS; U10HD21397/HD/NICHD NIH HHS; UL1 RR24139/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS; UL1 TR000142/TR/NCATS NIH HHS
Investigator
Investigator/Affiliation:
Michael S Caplan / ; William Oh / ; Betty R Vohr / ; Barbara Alksninis / ; Bonnie E Stephens / ; Yvette Yatchmink / ; Robert Burke / ; Angelita M Hensman / ; Teresa M Leach / ; Martha R Leonard / ; Lucy Noel / ; Rachel A Vogt / ; Victoria E Watson / ; Suzy Ventura / ; Avroy A Fanaroff / ; Deanne E Wilson-Costello / ; Nancy S Newman / ; Bonnie S Siner / ; Harriet G Friedman / ; Kurt Schibler / ; Edward F Donovan / ; Jean J Steichen / ; Kimberly Yolton / ; Barbara Alexander / ; Kate Bridges / ; Cathy Grisby / ; Marcia Worley Mersmann / ; Holly L Mincey / ; Jody Hessling / ; Teresa L Gratton / ; Ronald N Goldberg / ; C Michael Cotten / ; Kathy J Auten / ; Kimberley A Fisher / ; Katherine A Foy / ; Kathryn E Gustafson / ; Melody B Lohmeyer / ; David P Carlton / ; Ira Adams-Chapman / ; Sheena Carter / ; Elisabeth Dinkin / ; Ellen C Hale / ; Maureen Mulligan LaRossa / ; Gloria V Smikle / ; Linda L Wright / ; Elizabeth M McClure / ; Stephanie Wilson Archer / ; Ivan D Frantz / ; Elisabeth C McGowan / ; Brenda L MacKinnon / ; Ellen Nylen / ; Anne Furey / ; Cecelia Sibley / ; Ana Brussa / ; Brenda B Poindexter / ; James A Lemons / ; Anna M Dusick / ; Carolyn Lytle / ; Lon G Bohnke / ; Greg Eaken / ; Dianne E Herron / ; Lucy C Miller / ; Heike M Minnich / ; Leslie Richard / ; Leslie Dawn Wilson / ; Faithe Hamer / ; W Kenneth Poole / ; Dennis Wallace / ; Jeanette O'Donnell Auman / ; Margaret Cunningham / ; Betty K Hastings / ; ElizabethM McClure / ; Carolyn M Petrie Huitema / ; Kristin M Zaterka-Baxter / ; Krisa P Van Meurs / ; David K Stevenson / ; Susan R Hintz / ; M Bethany Ball / ; Marian M Adams / ; Charles E Ahlfors / ; Joan M Baran / ; Barbara Bentley / ; Lori E Bond / ; Ginger K Brudos / ; Alexis S Davis / ; Maria Elena DeAnda / ; Anne M DeBattista / ; Jan T Epcar / ; Barry E Fleisher / ; Magdy Ismael / ; Jean G Kohn / ; Carol G Kuelper / ; Julie C Lee-Ancajas / ; Melinda S Proud / ; Renee P Pyle / ; Dharshi Sivakuma / ; Robert D Stebbins / ; Nicholas H St John / ; Waldemar A Carlo / ; Namasivayam Ambalavanan / ; Myriam Peralta-Carcelen / ; Kathleen G Nelson / ; Kirstin J Bailey / ; Fred J Biasini / ; Stephanie A Chopko / ; Monica V Collins / ; Shirley S Cosby / ; Mary Beth Moses / ; Vivien A Phillips / ; Julie Preskitt / ; Richard V Rector / ; Sally Whitley / ; Neil N Finer / ; Yvonne E Vaucher / ; Maynard R Rasmussen / ; Paul R Wozniak / ; Kathy Arnell / ; Renee Bridge / ; Clarence Demetrio / ; Martha G Fuller / ; Donna Posin / ; Wade Rich / ; John A Widness / ; Michael J Acarregui / ; Karen J Johnson / ; Diane L Eastman / ; Nancy J Krutzfield / ; Charles R Bauer / ; Shahnaz Duara / ; Ruth Everett-Thomas / ; Amy Mur Worth / ; Mary Allison / ; Alexis N Diaz / ; Elaine O Mathews / ; Kasey Hamlin-Smith / ; Lisa Jean / ; Maria Calejo / ; Silvia M Frade Eguaras / ; Silvia Hiriart-Fajardo / ; Yamiley C Gideon / ; Alexandra Stoerger / ; Andrea Garcia / ; Helena Pierre / ; Kristi L Watterberg / ; Lu-Ann Papile / ; Robin K Ohls / ; Backstrom Lacy / ; Jean R Lowe / ; Rebecca Montman / ; Dale L Phelps / ; Ronnie Guillet / ; Gary J Myers / ; Linda J Reubens / ; Erica Burnell / ; Mary Rowan / ; Julie Babish Johnson / ; Rosemary L Jensen / ; Emily Kushner / ; Joan Merzbach / ; Lauren Zwetsch / ; Kelly Yost / ; Sheldon B Korones / ; Henrietta S Bada / ; Tina Hudson / ; Marilyn Williams / ; Kimberly Yolton / ; Pablo J Sánchez / ; Abbot R Laptook / ; Charles R Rosenfeld / ; Walid A Salhab / ; R Sue Broyles / ; Roy J Heyne / ; Sally S Adams / ; Cathy Twell / ; Cristin Dooley / ; Alicia Guzman / ; Elizabeth Heyne / ; Jackie F Hickman / ; Melissa H Leps / ; Linda A Madden / ; Nancy A Miller / ; Janet S Morgan / ; Susie Madison / ; Gaynelle Hensley / ; Diana M Vasil / ; Lizette E Torres / ; Jon E Tyson / ; Kathleen A Kennedy / ; Esther G Akpa / ; Patty A Cluff / ; Beverly Foley Harris / ; Claudia I Franco / ; Anna E Lis / ; Sarah Martin / ; Georgia E McDavid / ; Patti L Pierce Tate / ; Maegan C Simmons / ; Patricia Evans / ; Nora I Alaniz / ; Pamela J Bradt / ; Susan Dieterich / ; Charles Green / ; Margarita Jimine / ; Terri Major-Kincade / ; Brenda H Morris / ; M Layne Poundstone / ; Saba Siddiki / ; Maegan C Simmons / ; Laura L Whitely / ; Sharon L Wright / ; Roger G Faix / ; Bradley A Yoder / ; Anna Bodnar / ; Mike Steffens / ; Jill Burnett / ; Jennifer J Jensen / ; Karen A Osborne / ; Cynthia Spencer / ; Kimberlee Weaver-Lewis / ; T Michael O'Shea / ; Nancy J Peters / ; Korinne Chiu / ; Deborah Evans Allred / ; Donald J Goldstein / ; Raquel Halfond / ; Barbara G Jackson / ; Carroll Peterson / ; Ellen L Waldrep / ; Melissa Whalen Morris / ; Gail Wiley Hounshell / ; Yvette R Johnson / ; Rebecca Bara / ; Debra Driscoll / ; Laura Goldston / ; Deborah Kennedy / ; Geraldine Muran / ; Richard A Ehrenkranz / ; Harris Jacob / ; Patricia Cervone / ; Patricia Gettner / ; Nancy Close / ; Walter Gilliam / ; Monica Konstantino / ; JoAnn Poulsen / ; Elaine Romano / ; Janet Taft / ; Joanne Williams / ; Christine Butle / ; Sheila Greisman /
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