Document Detail

Risk factors for intestinal failure in infants with necrotizing enterocolitis: a Glaser Pediatric Research Network study.
MedLine Citation:
PMID:  20447649     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine risk factors for intestinal failure (IF) in infants undergoing surgery for necrotizing enterocolitis (NEC).
STUDY DESIGN: Infants were enrolled in a multicenter prospective cohort study. IF was defined as the requirement for parenteral nutrition for >or= 90 days. Logistic regression was used to identify predictors of IF.
RESULTS: Among 473 patients enrolled, 129 had surgery and had adequate follow-up data, and of these patients, 54 (42%) developed IF. Of the 265 patients who did not require surgery, 6 (2%) developed IF (OR 31.1, 95% CI, 12.9 - 75.1, P < .001). Multivariate analysis identified the following risk factors for IF: use of parenteral antibiotics on the day of NEC diagnosis (OR = 16.61, P = .022); birth weight < 750 grams, (OR = 9.09, P < .001); requirement for mechanical ventilation on the day of NEC diagnosis (OR = 6.16, P = .009); exposure to enteral feeding before NEC diagnosis (OR=4.05, P = .048); and percentage of small bowel resected (OR = 1.85 per 10 percentage point greater resection, P = .031).
CONCLUSION: The incidence of IF among infants undergoing surgical treatment for NEC is high. Variables characteristic of severe NEC (low birth weight, antibiotic use, ventilator use, and greater extent of bowel resection) were associated with the development of IF.
Debora Duro; Leslie A Kalish; Patrick Johnston; Tom Jaksic; Maggie McCarthy; Cami Martin; James C Y Dunn; Mary Brandt; Kerilyn K Nobuhara; Karl G Sylvester; R Lawrence Moss; Christopher Duggan
Related Documents :
16855619 - Can delivery room management impact the length of hospital stay in premature infants?
20664299 - Necrotizing enterocolitis in infants with periventricular hemorrhagic infarction: assoc...
11360059 - Gastric perforation. an unusual cause of ascites in a newborn baby.
2738829 - Gangrenous acalculous cholecystitis in a premature infant.
15116129 - A rare cause of intestinal perforation in an extreme low birth weight infant--gastroint...
11264029 - Ophthalmologic, visceral, and cardiac involvement in neonates with candidemia.
23744589 - Confounding underlies the apparent month of birth effect in multiple sclerosis.
11999149 - Optical considerations in the contact lens correction of infant aphakia.
21539529 - Non-invasive prediction of fluid responsiveness in infants using pleth variability index.
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-06
Journal Detail:
Title:  The Journal of pediatrics     Volume:  157     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-08-09     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-208.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Birth Weight
Cohort Studies
Enterocolitis, Necrotizing / complications*,  diagnosis*,  surgery
Gestational Age
Infant, Newborn
Multivariate Analysis
Odds Ratio
Pediatrics / methods
Prospective Studies
Risk Factors
Short Bowel Syndrome / complications*,  diagnosis*,  surgery
Grant Support
K24 HD058795/HD/NICHD NIH HHS; P30 DK040561/DK/NIDDK NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS; P30 DK40561-13/DK/NIDDK NIH HHS; T32-HD43034-05A1/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multi-site randomized controlled trial of a child-centered physical activity program, a parent-cente...
Next Document:  A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response ...