Document Detail

Risk factors for cortical, nuclear, posterior subcapsular, and mixed lens opacities: the Los Angeles Latino Eye Study.
MedLine Citation:
PMID:  22197433     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To identify sociodemographic and biological risk factors associated with having cortical, nuclear, posterior subcapsular (PSC), and mixed lens opacities.
DESIGN: Population-based, cross-sectional study.
PARTICIPANTS: A total of 5945 Latinos aged ≥ 40 years from 6 census tracts in Los Angeles, California.
METHODS: Participants underwent an interview and detailed eye examination, including best-corrected visual acuity and slit-lamp assessment of lens opacities using the Lens Opacities Classification System II. Univariate and stepwise logistic regression analyses were used to identify independent risk factors associated with each type of lens opacity.
MAIN OUTCOME MEASURES: Odds ratios for sociodemographic and biological risk factors associated with cortical only, nuclear only, PSC only, and mixed lens opacities.
RESULTS: Of the 5945 participants with gradable lenses, 468 had cortical only lens opacities, 217 had nuclear only lens opacities, 27 had PSC only opacities, and 364 had mixed lens opacities. Older age, higher hemoglobin A(1c), and history of diabetes mellitus were independent risk factors for cortical only lens opacities. Older age, smoking, and myopic refractive error were independent risk factors for nuclear only lens opacities. Higher systolic blood pressure and history of diabetes were independent risk factors for PSC lens opacities. Older age, myopic refractive error, history of diabetes, higher systolic blood pressure, female gender, and presence of large drusen were independent risk factors for mixed lens opacities.
CONCLUSIONS: The modifiable and non-modifiable risk factors identified in this study provide insight into the mechanisms related to the development of lens opacification. Improved glycemic control, smoking cessation and prevention, and blood pressure control may help to reduce the risk of having lens opacities and their associated vision loss.
Grace M Richter; Mina Torres; Farzana Choudhury; Stanley P Azen; Rohit Varma;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-23
Journal Detail:
Title:  Ophthalmology     Volume:  119     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-04-27     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Age Factors
Aged, 80 and over
Cataract / diagnosis,  ethnology*
Cross-Sectional Studies
Diabetes Mellitus / ethnology
Hispanic Americans / ethnology*
Hypertension / ethnology
Lens Cortex, Crystalline / pathology*
Lens Nucleus, Crystalline / pathology*
Los Angeles / epidemiology
Middle Aged
Myopia / ethnology
Odds Ratio
Population Groups
Posterior Capsule of the Lens / pathology*
Retinal Drusen / ethnology
Risk Factors
Sex Factors
Visual Acuity / physiology
Grant Support
EY-03040/EY/NEI NIH HHS; NEI U10-EY-11753/EY/NEI NIH HHS; U10 EY011753/EY/NEI NIH HHS; U10 EY011753-02/EY/NEI NIH HHS; U10 EY011753-03/EY/NEI NIH HHS; U10 EY011753-03S1/EY/NEI NIH HHS; U10 EY011753-03S2/EY/NEI NIH HHS; U10 EY011753-03S3/EY/NEI NIH HHS; U10 EY011753-03S4/EY/NEI NIH HHS; U10 EY011753-03S5/EY/NEI NIH HHS; U10 EY011753-04/EY/NEI NIH HHS; U10 EY011753-04S1/EY/NEI NIH HHS; U10 EY011753-05/EY/NEI NIH HHS; U10 EY011753-06/EY/NEI NIH HHS; U10 EY011753-07/EY/NEI NIH HHS; U10 EY011753-07S1/EY/NEI NIH HHS; U10 EY011753-08/EY/NEI NIH HHS; U10 EY011753-08S1/EY/NEI NIH HHS; U10 EY011753-09/EY/NEI NIH HHS; U10 EY011753-10/EY/NEI NIH HHS; U10 EY011753-11A1/EY/NEI NIH HHS; U10 EY011753-12/EY/NEI NIH HHS; U10 EY011753-13/EY/NEI NIH HHS

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