| Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation. | |
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MedLine Citation:
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PMID: 19797900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Central pontine myelinolysis (CPM)/extrapontine myelinolysis (EPM) is one of the most serious neurological complications that can occur after orthotopic liver transplantation (OLT). We analyzed the risk factors for CPM/EPM in OLT patients. METHODS: We retrospectively reviewed the records of 1,247 patients who underwent OLT between 1992 and 2005. We compared demographic, clinical and biological parameters of patients with CPM/EPM with those of age-, sex- and operation date-matched patients without CPM/EPM (controls). RESULTS: Of 1,247 patients, 11 (0.88%) were diagnosed with CPM/EPM based on neuroimaging findings. A higher Model for End-Stage Liver Disease-Na score, preoperative hyponatremia and hypocholesterolemia, as well as greater changes in electrolytes, especially sodium, during surgery, were observed in the CPM/EPM group (p < 0.05). CONCLUSION: CPM/EPM after OLT is more likely to occur in patients with more severe preoperative liver dysfunction and greater changes in electrolyte imbalance, especially sodium, during surgery. |
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Authors:
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Eun Mi Lee; Joong Koo Kang; Sung-Cheol Yun; Ki-Hun Kim; Sang Joon Kim; Kyu-Sam Hwang; Sung-Gyu Lee |
Publication Detail:
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Type: Journal Article Date: 2009-09-30 |
Journal Detail:
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Title: European neurology Volume: 62 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 362-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Hyponatremia / complications Liver Transplantation / adverse effects* Male Middle Aged Monitoring, Intraoperative Myelinolysis, Central Pontine / complications*, diagnosis Predictive Value of Tests Risk Factors Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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