| Risk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension. | |
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MedLine Citation:
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PMID: 20532019 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic dysfunction. Some studies have shown that diabetes itself may also be an independent risk factor for LV diastolic dysfunction, although this is controversial. The aim of this study was to determine the factors associated with LV diastolic dysfunction in patients with type 2 diabetes in the absence of hypertension or ischemic heart disease (IHD). METHODS: Participants in this study consisted of 65 type 2 diabetes patients (M : F = 45 : 20; mean age 51 [26 to 76] years; mean body mass index [BMI] 25.0 +/- 2.5 kg/m(2)) without hypertension, heart disease, or renal disease. Individuals with ischemic electrocardiographic changes were excluded. LV diastolic function was evaluated by Doppler echocardiographic studies. RESULTS: Fifteen patients (23.1%) showed LV diastolic dysfunction on Doppler echocardiographic studies. Patients with LV diastolic dysfunction were older than those without diastolic dysfunction (60.0 +/- 2.5 vs. 50.5 +/- 1.9 years; P < 0.01). After adjusting for age and sex, BMI was higher (26.6 +/- 0.7 vs. 24.6 +/- 0.3 kg/m(2); P < 0.01) and diabetes duration was longer (9.65 +/- 1.48 vs. 4.71 +/- 0.78 years; P < 0.01) in patients with LV diastolic dysfunction than in those without diastolic dysfunction. There were no differences in sex, smoking, blood pressure, lipid profiles, hemoglobin A(1)C, fasting glucose, fasting insulin, or diabetic microvascular complications between the LV diastolic dysfunction group and the normal diastolic function group. After adjusting for age, sex, and BMI, diabetes duration was found to be independently associated with LV diastolic dysfunction (odds ratio 1.38; confidence interval 1.12 to 1.72; P = 0.003). CONCLUSION: These results suggest that diabetes duration may be a risk factor for LV diastolic dysfunction in type 2 diabetic patients without hypertension or IHD. |
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Authors:
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Jung Hyun Noh; Joon Hyung Doh; Sung Yun Lee; Tae Nyun Kim; Hyuk Lee; Hwa Young Song; Jeong Hyun Park; Kyung Soo Ko; Byoung Doo Rhee; Dong Jun Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-02-28 |
Journal Detail:
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Title: Korean diabetes journal Volume: 34 ISSN: 2093-2650 ISO Abbreviation: Korean Diabetes J Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-06-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477168 Medline TA: Korean Diabetes J Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Inje University College of Medicine, Goyang, Korea. |
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