Document Detail

Risk determinants in individuals with a spontaneous type 1 Brugada ECG.
MedLine Citation:
PMID:  21343656     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Spontaneous coved ST-segment elevation ≥2 mm followed by a negative T-wave in the right precordial leads (type 1 Brugada ECG) is diagnostic of Brugada syndrome (BS), but there is a false-positive rate.
METHODS AND RESULTS: Computer-processed analysis of a 12-lead ECG database containing 49,286 females and 52,779 males was performed to select patients with a spontaneous type 1 Brugada ECG for an examination of the association of this ECG characteristic with long-term prognosis. There were 185 patients with a spontaneous type 1 Brugada ECG and of these, 16 (15 males; mean age, 46.7±14.0 years) were diagnosed with BS and 15 patients (all males; mean age, 50.1±13.4 years) were undiagnosed. The PQ interval was significantly longer in the diagnosed patients than in the undiagnosed patients (187.4±28.3 ms vs. 161.2±21.5 ms; P=0.0073). The T-wave in lead V(1) was more negative in the diagnosed patients than in the undiagnosed patients (-170.2±174.6 µV vs. -43.2±122.3 µV, P=0.027). Multivariate analysis revealed that a PQ interval ≥170 ms and T-wave amplitude <105 µV in lead V(1) were independent risk stratifiers of life-threatening events. Survival analysis (mean follow-up, 78.6±81.8 months) showed that the PQ interval and a negative T-wave in lead V(1) were significantly associated with poor prognosis.
CONCLUSIONS: Analysis of a standard 12-lead ECG can stratify the prognosis of patients with a spontaneous type 1 Brugada ECG.
Akashi Miyamoto; Hideki Hayashi; Takeru Makiyama; Tomohide Yoshino; Yuka Mizusawa; Yoshihisa Sugimoto; Makoto Ito; Joel Q Xue; Yoshitaka Murakami; Minoru Horie
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Publication Detail:
Type:  Journal Article     Date:  2011-02-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-08-12     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  844-51     Citation Subset:  IM    
Copyright Information:
All rights are reserved to the Japanese Circulation Society.
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.
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MeSH Terms
Brugada Syndrome / diagnosis*,  mortality,  physiopathology
Diagnosis, Computer-Assisted / methods*
Electrocardiography / methods*
Middle Aged
Retrospective Studies
Risk Factors
Survival Rate
Comment In:
Circ J. 2011;75(4):777-8   [PMID:  21378447 ]

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