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Risk of Coronary Artery Disease in Women with History of Pregnancies Complicated by Preeclampsia and LBW.
MedLine Citation:
PMID:  21923611     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Women with a history of pregnancy complicated by preeclampsia or Intrauterine growth restriction and low infant birth weight looks at a higher risk for subsequent ischemic heart disease. Objective: To determine the relationship between pregnancy complications and maternal coronary artery disease in the future. Material and method: We performed a case - control study on 690 of patients (345 patients in each group) referred to Tehran Heart Center. Women with coronary artery disease were in the case group and women without coronary artery disease were in the control group. The history of pregnancy complications (including preeclampsia, low birth weight delivery, preterm labor and gestational hypertension) evaluated in two groups. Results: 12.5% of patients in case group had a history of preeclampsia, compared with the control group (1.7%). (P <0. 0001). 7% of patients in case group and 0.9% of patients in control group had history of low birth weight delivery. The difference was significant (P <0.0001). A history of preterm labor was recorded in 11% of cases and 3.2% of controls. Performing Multivariate analysis showed that there is a strong association between preeclampsia and coronary artery disease (OR: 16.92; 95% CI; P <0.0001), low birth weight delivery and coronary artery disease (OR: 6.52; 95% CI; P: 0.0038), also between high parity and coronary artery disease. (OR: 1.135; 95% CI; P: 0.0479). Conclusion: Our results suggest preeclampsia, low birth weight delivery and high parity of the mother as independent risk factors for coronary artery disease in the future.
Authors:
Sedigheh Borna; Ebrahim Neamatipoor; Narges Radman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Tehran university of medical siences, Tehran, Iran.
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