| Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. | |
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MedLine Citation:
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PMID: 22289873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Patients with ulcerative colitis (UC) have an increased risk of developing colorectal cancer (CRC). Studies examining the magnitude of this association have yielded conflicting results. We performed a meta-analysis of population-based cohort studies to determine the risk of CRC in patients with UC. METHODS: We used MEDLINE, EMBASE, Cochrane, and CINAHL to perform a systematic literature search. We included 8 studies in the meta-analysis on the basis of strict inclusion and exclusion criteria. We calculated pooled standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) for risk of CRC in patients with UC and performed meta-regression analyses of the effect of cohort size, calendar period, observation time, percentage with proctitis, and rates of colectomy on the risk of CRC. RESULTS: An average of 1.6% of patients with UC was diagnosed with CRC during 14 years of follow-up. SIRs ranged from 1.05 to 3.1, with a pooled SIR of 2.4 (95% CI, 2.1-2.7). Men with UC had a greater risk of CRC (SIR, 2.6; 95% CI, 2.2-3.0) than women (SIR, 1.9; 95% CI, 1.5-2.3). Young age was a risk factor for CRC (SIR, 8.6; 95% CI, 3.8-19.5; although this might have resulted from small numbers), as was extensive colitis (SIR, 4.8; 95% CI, 3.9-5.9). In meta-regression analyses, only cohort size was associated with risk of CRC. CONCLUSIONS: In population-based cohorts, UC increases the risk of CRC 2.4-fold. Male sex, young age at diagnosis with UC, and extensive colitis increase the risk. |
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Authors:
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Tine Jess; Christine Rungoe; Laurent Peyrin-Biroulet |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2012-01-28 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 10 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-25 Completed Date: 2012-09-19 Revised Date: 2012-11-20 |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 639-45 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. tjs@ssi.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Cohort Studies Colitis, Ulcerative / complications*, pathology Colorectal Neoplasms / epidemiology* Female Humans Incidence Male Risk Assessment Sex Factors |
| Comments/Corrections | |
Comment In:
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Clin Gastroenterol Hepatol. 2012 Oct;10(10):1179; author reply 1179-80
[PMID:
22610004
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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