| Risk of Barrett's oesophagus, oesophageal adenocarcinoma and reflux oesophagitis and the use of nitrates and asthma medications. | |
| | |
MedLine Citation:
|
PMID: 20626305 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the relationship between use of asthma medication and nitrates and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. MATERIAL AND METHODS: Data were collected on use of asthma medication and nitrates at least 1 year before interview from patients with reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Associations between use of asthma medications and nitrates and the risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma were estimated using multiple logistic regression. RESULTS: Nine hundred and forty-one subjects were recruited: 230 reflux oesophagitis, 224 Barrett's oesophagus, 227 oesophageal adenocarcinoma patients and 260 population controls. Barrett's oesophagus patients were more likely than controls to have had a diagnosis of asthma (odds ratio 2.15, 95% confidence interval 1.15-4.03) and to have used asthma medications (odds ratio 2.13, 95% confidence interval 1.09-4.16). No significant associations were observed between use of asthma medication or nitrates and reflux oesophagitis or oesophageal adenocarcinoma. CONCLUSIONS: Gastro-oesophageal reflux symptoms appear to confound the association between asthma medication use and Barrett's oesophagus. However, it is possible that asthma medications may increase the risk of Barrett's oesophagus by other mechanisms. |
| | |
Authors:
|
Todd C Ladanchuk; Brian T Johnston; Liam J Murray; Lesley A Anderson; |
Related Documents
:
|
19945775 - Onions, myths, beliefs, fashion and reality in asthma. 12797875 - Acute asthma. 8494195 - Medical chronobiology: concepts and applications. 9139775 - Alternative therapies for asthma. 15157815 - The relationship between experiential avoidance and the severity of trichotillomania in... 6454705 - Relationship of depression to medical illness. a critical review. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-14 |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 45 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: England |
Other Details:
|
Languages: eng Pagination: 1397-403 Citation Subset: IM |
Affiliation:
|
Centre for Public Health, Queen's University, and Royal Group of Hospitals, Belfast, Northern Ireland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Investigator | |
Investigator/Affiliation:
|
L J Murray / ; L A Anderson / ; B T Johnston / ; R G P Watson / ; J McGuigan / ; H R Ferguson / ; S J Murphy / ; J V Reynolds / ; H Comber / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: the utility and impact on ...
Next Document: Intestinal malabsorption of D-xylose: comparison of test modalities in patients with celiac disease.