| Risk of asthma in young adults who were born preterm: a Swedish national cohort study. | |
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MedLine Citation:
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PMID: 21422091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Preterm birth is associated with asthma-like symptoms in childhood and possibly in adolescence, but the longer-term risk of asthma is unknown and increasingly relevant as larger numbers of these individuals enter adulthood. Our objective was to evaluate whether those who were born preterm are more likely to be prescribed asthma medications in young adulthood than those who were born term. PATIENTS AND METHODS: We conducted a national cohort study of all singleton infants born in Sweden from 1973 through 1979 (n = 622 616), followed to ages 25.5 to 35.0 years to determine whether asthma medications were prescribed in 2005-2007. Asthma medication data were obtained from all outpatient and inpatient pharmacies throughout Sweden. To improve the positive predictive value for asthma, the outcome was defined as prescription of (1) both a β-2 agonist inhalant and a glucocorticoid inhalant or (2) a combination inhalant containing a β-2 agonist and other drugs for obstructive airway diseases. RESULTS: Young adults who were born extremely preterm (23-27 weeks' gestation) were 2.4 times more likely (adjusted 95% CI: 1.41-4.06) to be prescribed asthma medications than those who were born term. No association was found between later preterm birth (28-32 or 33-36 weeks' gestation) and asthma medications in young adulthood. CONCLUSIONS: This is the first study with sufficient statistical power to evaluate the risk of asthma beyond adolescence in individuals who were born extremely preterm. The results suggest that extreme preterm birth (23-27 weeks' gestation), but not later preterm birth, is associated with an increased risk of asthma at least into young adulthood. |
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Authors:
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Casey Crump; Marilyn A Winkleby; Jan Sundquist; Kristina Sundquist |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-21 |
Journal Detail:
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Title: Pediatrics Volume: 127 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-05-31 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e913-20 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Stanford University, Palo Alto, California, USA. kccrump@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Asthmatic Agents / therapeutic use Asthma / drug therapy, epidemiology* Child Child, Preschool Cohort Studies Female Gestational Age Health Surveys Humans Infant Infant, Extremely Low Birth Weight Infant, Newborn Infant, Premature, Diseases / drug therapy, epidemiology* Infant, Very Low Birth Weight Longitudinal Studies Male Pregnancy Risk Factors Sex Factors Socioeconomic Factors Sweden Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R01DA030005-01A1/DA/NIDA NIH HHS; 1R01HD052848-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents |
| Comments/Corrections | |
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