Document Detail

Risk of asthma in young adults who were born preterm: a Swedish national cohort study.
MedLine Citation:
PMID:  21422091     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Preterm birth is associated with asthma-like symptoms in childhood and possibly in adolescence, but the longer-term risk of asthma is unknown and increasingly relevant as larger numbers of these individuals enter adulthood. Our objective was to evaluate whether those who were born preterm are more likely to be prescribed asthma medications in young adulthood than those who were born term.
PATIENTS AND METHODS: We conducted a national cohort study of all singleton infants born in Sweden from 1973 through 1979 (n = 622 616), followed to ages 25.5 to 35.0 years to determine whether asthma medications were prescribed in 2005-2007. Asthma medication data were obtained from all outpatient and inpatient pharmacies throughout Sweden. To improve the positive predictive value for asthma, the outcome was defined as prescription of (1) both a β-2 agonist inhalant and a glucocorticoid inhalant or (2) a combination inhalant containing a β-2 agonist and other drugs for obstructive airway diseases.
RESULTS: Young adults who were born extremely preterm (23-27 weeks' gestation) were 2.4 times more likely (adjusted 95% CI: 1.41-4.06) to be prescribed asthma medications than those who were born term. No association was found between later preterm birth (28-32 or 33-36 weeks' gestation) and asthma medications in young adulthood.
CONCLUSIONS: This is the first study with sufficient statistical power to evaluate the risk of asthma beyond adolescence in individuals who were born extremely preterm. The results suggest that extreme preterm birth (23-27 weeks' gestation), but not later preterm birth, is associated with an increased risk of asthma at least into young adulthood.
Casey Crump; Marilyn A Winkleby; Jan Sundquist; Kristina Sundquist
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-21
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-05-31     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e913-20     Citation Subset:  AIM; IM    
Department of Medicine, Stanford University, Palo Alto, California, USA.
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MeSH Terms
Anti-Asthmatic Agents / therapeutic use
Asthma / drug therapy,  epidemiology*
Child, Preschool
Cohort Studies
Gestational Age
Health Surveys
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / drug therapy,  epidemiology*
Infant, Very Low Birth Weight
Longitudinal Studies
Risk Factors
Sex Factors
Socioeconomic Factors
Young Adult
Grant Support
1R01DA030005-01A1/DA/NIDA NIH HHS; 1R01HD052848-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Anti-Asthmatic Agents

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