Document Detail


Rising plasma levels of 19-nortestosterone throughout pregnancy: determination by radioimmunoassay and validation by gas chromatography-mass spectrometry.
MedLine Citation:
PMID:  3558726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A highly sensitive and specific radioimmunoassay was developed to measure 19-nortestosterone (NT), which allowed us to demonstrate this steroid in the plasma of pregnant women. Plasma NT was detectable throughout gestation, reaching values of 12 to 60 pg/ml in the 3rd trimester. These results were validated by gas chromatography-mass spectrometry. No NT was detectable in the plasma of 12 normal men and 12 nonpregnant women in the mid follicular phase of their cycle (detection limit 4 pg/ml). Our results are compatible with current concepts concerning the possible involvement of 19-norsteroids in an accessory biosynthetic pathway for estrogen in the placenta.
Authors:
Y Reznik; M Herrou; L Dehennin; M Lemaire; P Leymarie
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1086-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Microchemistry
Nandrolone / blood*
Pregnancy / blood*
Radioimmunoassay
Chemical
Reg. No./Substance:
434-22-0/Nandrolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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