| Riser's reflux--an eye-opening experience. | |
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MedLine Citation:
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PMID: 20059700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with gastro-oesophageal reflux disease (GORD) commonly report waking up in the morning with a sour or bitter taste in their mouth. The aim of the study was to compare the prevalence and frequency of acid reflux events prior to and immediately after awakening from sleep in the morning between GORD patients and normal subjects. METHODS: Thirty-nine patients with heartburn at least three times a week and abnormal pH test and nine healthy controls were included. All subjects were evaluated by demographic and GORD Symptom Checklist questionnaires. Subjects underwent pH testing concomitantly with actigraphy. A novel technology that simultaneously integrates raw actigraphy and pH monitoring data was utilized to determine the presence, frequency, and characteristics of acid reflux events prior to (up to 1 h) and immediately after (10 and 20 min) awakening from sleep in the morning. KEY RESULTS: Nineteen (48.7%) of the GORD patients had an acid reflux event within the first 20 min after awakening from sleep in the morning as compared to only seven (17.9%) during the hour prior to awakening. Within the first 10 and 20 min after awakening, patients had a total of 32 and 60 acid reflux events, respectively, as compared to 14 during the 1 h prior to awakening (P < 0.05). None of the healthy control patients demonstrated any reflux events during these three studied periods (P < 0.001). CONCLUSIONS & INFERENCES: Riser's reflux is very common among GORD patients and possibly may explain reports of early-morning GORD symptoms. |
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Authors:
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C-H Poh; L Allen; I Malagon; A Gasiorowska; T Navarro-Rodriguez; J Powers; B Moty; M R Willis; S F Quan; R Fass |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-05 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 22 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-09 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Affiliation:
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Department of Medicine, Southern Arizona VA Health Care System, University Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actigraphy
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methods Adult Aged Aged, 80 and over Chi-Square Distribution Circadian Rhythm / physiology* Electric Impedance Esophageal pH Monitoring Female Gastroesophageal Reflux / physiopathology* Humans Male Middle Aged Questionnaires Severity of Illness Index Sleep* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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