Document Detail

Rise of blood pressure with age. New evidence of population differences.
MedLine Citation:
PMID:  7995637     Owner:  NLM     Status:  MEDLINE    
Epstein and Eckoff in 1967 devised a scheme to summarize population differences in the rise of mean values of systolic blood pressure by age in accordance with their slopes and levels. For the first time, the validity of this scheme can be examined with data from a single study, INTERSALT. This study included 52 populations in 32 countries. On the basis of these data, collected in an exceptionally well-standardized mode under a common protocol, the diversity of populations in the slopes of age differences in median values of systolic blood pressure has been strongly reconfirmed. Populations with no increase in median systolic blood pressure were again observed and remained exceptional. The analyses of these data also indicate a positive relation between the slope of rising systolic blood pressure with age and urinary sodium, urinary sodium-potassium ratio, and reported alcohol consumption as well as a negative association between urinary potassium excretion and blood pressure slope. The present analyses therefore add to the previous knowledge and results published by the INTERSALT investigators in the following three respects: (1) they relate INTERSALT results to the postulated biological gradient of variation among populations as presented by Epstein and Eckoff, including explanatory variables; (2) they demonstrate strong correlation between ranks of median blood pressure at 40 to 49 years and values at 20 to 29 years; and (3) they therefore support the original Epstein and Eckoff concept of population variation, link this with blood pressure risk factors, and call attention to the large degree of population differences already evident among populations at 20 to 29 years of age.
B L Rodriguez; D R Labarthe; B Huang; J Lopez-Gomez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  24     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-18     Completed Date:  1995-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  779-85     Citation Subset:  IM    
Southwest Center for Prevention Research, University of Texas Health Science Center, Houston 77225.
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MeSH Terms
Aging / physiology*
Alcohol Drinking
Blood Pressure / physiology*
Body Mass Index
Middle Aged
Potassium / urine
Regression Analysis
World Health*
Reg. No./Substance:

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