Document Detail


Ripening of the human cervix with porcine ovarian relaxin.
MedLine Citation:
PMID:  6353927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent experience has suggested that porcine ovarian relaxin may promote cervical changes. We have performed two double-blind randomized studies: (1) comparing cervical changes with relaxin versus placebo during oxytocic labor induction and (2) as outpatients in postdates pregnancies. In the induction study, cervical changes were speeded up by both 2 and 4 mg doses of relaxin, and times to delivery were decreased. In the outpatient study, 2 mg doses of relaxin produced greater cervical changes than did control or 4 mg doses. We conclude that relaxin may have benefit in ripening of the cervix. Since relaxin works directly on the cervix and not through uterine contractions, relaxin may have advantages in cervical ripening of pregnancies in which stress to the fetus is an issue.
Authors:
M I Evans; M B Dougan; A H Moawad; W J Evans; G D Bryant-Greenwood; F C Greenwood
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  147     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Ambulatory Care
Animals
Cervix Uteri / drug effects*
Clinical Trials as Topic
Dilatation / methods
Double-Blind Method
Female
Humans
Labor, Induced / methods*
Pregnancy
Relaxin / therapeutic use*
Swine
Grant Support
ID/Acronym/Agency:
RR08125-09/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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