| Rio de La Plata study: a multicenter, cross-sectional study on cardiovascular risk factors and heart failure prevalence in peritoneal dialysis patients in Argentina and Uruguay. | |
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MedLine Citation:
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PMID: 18379540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multicenter cross-sectional study was performed to evaluate the prevalence of heart failure (HF) and the associated cardiovascular (CV) risk factors in 298 peritoneal dialysis (PD) patients from Argentina and Uruguay, representing almost 30% of the total number of PD patients in the two countries. Bidimensional echocardiography, electrocardiography, and biochemical analysis were performed. Systolic HF was defined as an ejection fraction <50%. According to echocardiography, 84.6% showed left ventricular hypertrophy (LVH), 38.3% valvular heart disease, and 35.4% valvular calcification, whereas 20% showed intraventricular conduction disturbances on the electrocardiogram. The prevalence of CV risk factors was of 73% hypertension, 51% sedentarism, 18% diabetes, 16.8% obesity, 12% smokers, 42.3% phosphorus >5.5 mg per 100 ml, 42.3% parathyroid hormone>300 pg ml(-1), and 29.6% calcium phosphate product >55. The prevalence of systolic HF was 9.9%, being significantly associated with diabetes: odds ratio (OR)=4.11 (P<0.006) and hypoalbuminemia: OR=3.45 (P<0.011). Forty percent of patients with a diagnosis of left ventricular dysfunction at the time of the study were asymptomatic. Variables associated with LVH in the multivariate analysis were anemia (OR=4.06; P<0.001) and previous hemodialysis (OR=1.99; P<0.031). The identification of reversible risk factors associated to HF and the diagnosis of asymptomatic ventricular dysfunction in this PD population will lead our efforts to establish guidelines for prevention and early treatment of congestive HF in patients on PD. |
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Authors:
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G Moretta; A J Locatelli; L Gadola; J De Arteaga; L Solá; N Caporale; J Schargorodsky; E Ducasse; G Pastorino; N Marchetta; W Espeche; Z Ortiz |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Kidney international. Supplement Volume: - ISSN: 0098-6577 ISO Abbreviation: Kidney Int. Suppl. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7508622 Medline TA: Kidney Int Suppl Country: United States |
Other Details:
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Languages: eng Pagination: S159-64 Citation Subset: IM |
Affiliation:
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Centro Nefrológico Noroeste, Junín, Buenos Aires, Argentina. gmoretta@estudioriodelaplata.com.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Argentina / epidemiology Cardiovascular Diseases / epidemiology*, etiology* Chronic Disease Cross-Sectional Studies Female Heart Failure / epidemiology*, etiology* Humans Hypertrophy, Left Ventricular / epidemiology, etiology, ultrasonography Kidney Diseases / complications*, therapy Male Middle Aged Multivariate Analysis Peritoneal Dialysis* Prevalence Risk Factors Uruguay / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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