| Ringtail in suckling Munich Wistar Fromter rats: a histopathologic study. | |
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MedLine Citation:
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PMID: 11099138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ringtail is a pathologic condition of the tail of rats and other rodents that is traditionally attributed to low environmental humidity, although dietary deficiencies, genetic susceptibility, environmental temperature, and degree of hydration of the animal also have been suggested as possible causes. To the authors' knowledge, a detailed histopathologic study that may serve to shed light on the etiopathogenesis of this disease has not yet been published. We describe the histologic findings of ringtail observed in 12 suckling Munich Wistar Fromter (MWF) rats from two litters. Epidermal hyperplasia characterized by orthokeratotic and parakeratotic hyperkeratosis and acanthosis was observed in all affected rats. Numerous often dilated vessels were present in the dermis of tails that appeared of red/brown color at gross examination. In severe cases, the dilated vascular structures were thrombotic and accompanied by dermal hemorrhages and focal coagulative necrosis of the overlying epidermis. These findings suggest that epidermal acanthosis and hyperkeratosis are the main and primary events in the development of ringtail. To clarify the cause of this disease, future studies should be focused on the numerous factors that can induce such epidermal changes. |
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Authors:
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L Crippa; A Gobbi; R M Ceruti; C B Clifford; A Remuzzi; E Scanziani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Comparative medicine Volume: 50 ISSN: 1532-0820 ISO Abbreviation: Comp. Med. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-28 Completed Date: 2001-04-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100900466 Medline TA: Comp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 536-9 Citation Subset: IM |
Affiliation:
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Novuspharma, Monza, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Suckling Dietary Proteins / administration & dosage* Female Histocytochemistry / veterinary Male Rats Rats, Wistar / physiology* Rodent Diseases / etiology, pathology* Skin Diseases / etiology, pathology, veterinary* Tail / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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