Document Detail

Ring-enchancement in multiple sclerosis: marker of disease severity.
MedLine Citation:
PMID:  11475440     Owner:  NLM     Status:  MEDLINE    
Correlations between conventional MRI measures of disease activity and clinical disability in multiple sclerosis (MS) have been disappointing. Because ring-enhancing lesions may reflect a more destructive pathology, we tested their potential association with disease severity. We evaluated active lesions with regard to their enhancement pattern on serial magnetic resonance images in a cohort of 28 patients with relapsing-remitting MS. The percentage of ring-enhancing lesions correlated with EDSS, T2 lesion load and duration of disease and predicted the occurrence of relapses during the baseline period of observation as well as after 3 years of follow-up in multiple logistic regression analysis. The findings suggest that the pathological process reflected by ring-enhancing lesions may contribute to more severe clinical disease.
K Morgen; N O Jeffries; R Stone; R Martin; N D Richert; J A Frank; H F McFarland
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  7     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Cohort Studies
Logistic Models
Magnetic Resonance Imaging*
Multiple Sclerosis, Relapsing-Remitting / pathology*
Predictive Value of Tests
Severity of Illness Index*

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