Document Detail

Ring chromosomes in chronic myelogenous leukemia: an ominous finding.
MedLine Citation:
PMID:  3288814     Owner:  NLM     Status:  MEDLINE    
Two cases of Philadelphia chromosome positive chronic myelogenous leukemia (CML) demonstrated ring chromosomes. The appearance of the ring coincided with evolution from the stable to the aggressive phase. A literature search yielded six other cases of ring chromosomes in CML; all were in or were entering the aggressive phase of the disease. Thus, as is the case with acute nonlymphocytic leukemia, in CML the finding of an acquired ring chromosome is associated with a poor prognosis.
J P Lewis; H Jenks; P Walling
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Leukemia research     Volume:  12     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-28     Completed Date:  1988-07-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-83     Citation Subset:  IM    
Department of Medicine, University of California, School of Medicine, Davis 95616.
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MeSH Terms
Cell Transformation, Neoplastic
Chromosome Aberrations*
Leukemia, Myeloid / genetics*,  pathology
Ring Chromosomes*

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