Document Detail


Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival.
MedLine Citation:
PMID:  23449499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-cell factor/lymphoid enhancer factor (TCF/LEF) proteins regulate transcription by recruiting β-catenin and its associated co-regulators. Whether TCF/LEFs also recruit more factors through independent, direct interactions is not well understood. Here we discover Ring Finger Protein 14 (RNF14) as a new binding partner for all TCF/LEF transcription factors. We show that RNF14 positively regulates Wnt signalling in human cancer cells and in an in vivo zebrafish model by binding to target promoters with TCF and stabilizing β-catenin recruitment. RNF14 depletion experiments demonstrate that it is crucial for colon cancer cell survival. Therefore, we have identified a key interacting factor of TCF/β-catenin complexes to regulate Wnt gene transcription.
Authors:
Beibei Wu; Sarah Piloto; Weihua Zeng; Nate P Hoverter; Thomas F Schilling; Marian L Waterman
Related Documents :
9649439 - A specialized form of rna polymerase i, essential for initiation and growth-dependent r...
24956419 - Distinct regulation of the anterior and posterior myeloperoxidase expression by etv2 an...
23886199 - Hsa-mir-181a-5p expression and effects on cell proliferation in gastric cancer.
24954509 - Hsf1 regulation of β-catenin in mammary cancer cells through control of hur/elavl1 exp...
24446069 - Exendin-4 attenuates endoplasmic reticulum stress through a sirt1-dependent mechanism.
7987259 - Accurate transcription initiation by rna polymerase ii from candida utilis.
2685559 - A cis-acting element in the promoter region of the murine c-myc gene is necessary for t...
22363779 - Er-alpha-cdna as part of a bicistronic transcript gives rise to high frequency, long te...
7504119 - Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-03-01
Journal Detail:
Title:  EMBO reports     Volume:  14     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-02     Completed Date:  2013-09-19     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival
Colonic Neoplasms
Gene Expression Regulation, Neoplastic*
Gene Knockdown Techniques
HCT116 Cells
HEK293 Cells
Humans
Intracellular Signaling Peptides and Proteins / physiology*
Promoter Regions, Genetic
Protein Binding
RNA, Small Interfering / genetics
TCF Transcription Factors / metabolism*
Transcription, Genetic*
Up-Regulation
Wnt Signaling Pathway
Zebrafish
beta Catenin / metabolism*
Grant Support
ID/Acronym/Agency:
CA096878/CA/NCI NIH HHS; CA108697/CA/NCI NIH HHS; P30 CA062203/CA/NCI NIH HHS; P30CA062203/CA/NCI NIH HHS; P50 GM076516/GM/NIGMS NIH HHS; R01 CA096878/CA/NCI NIH HHS; R01 CA108697/CA/NCI NIH HHS; R01DE13828/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/CTNNB1 protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/RNA, Small Interfering; 0/RNF14 protein, human; 0/TCF Transcription Factors; 0/beta Catenin
Comments/Corrections
Comment In:
EMBO Rep. 2013 Apr;14(4):295-6   [PMID:  23478335 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epidemiology of the gynecological and mammary cancer to the HOMEL and in the CUGO Cotonou, Bénin.
Next Document:  Increased vegetable and fruit consumption during weight loss effort correlates with increased weight...