| Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure. | |
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MedLine Citation:
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PMID: 22425597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite its propensity to increase motivation for food consumption, marijuana use in humans has been associated with "amotivational syndrome." This "amotivational syndrome" can be characterized by a reduction in response persistence in tasks requiring sustained, but not maximal, effort. To examine this hypothesis, dose-effect functions for THC (0.03-10 mg/kg) and rimonabant (0.1-10 mg/kg) were first determined under a time-constrained PR 5 schedule. During the second phase of the study, doses of THC and rimonabant that did not affect the responses/total reinforced responses were chosen for further evaluation in a series of PR schedules with step sizes of PR 3, PR 5, PR 10, and PR exponential. THC and rimonabant produced decreases in responses per reinforcer, and response rate when behavior was maintained on a PR 5. Rimonabant also decreased session length. During the PR step size manipulation phase, rimonabant decreased responses/total reinforced responses, response rate, and session length, whereas THC only decreased response rate. These results are consistent with previous literature demonstrating that rimonabant decreases motivation for food both in cases where it is earned, as well as under free-feeding conditions, whereas the effects of cannabinoid agonists such as THC on responding for food exhibit greater dependence upon motivational and non-motivational factors, including workload and duration of the task. |
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Authors:
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Julie A Marusich; Jenny L Wiley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-03-09 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 101 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-04-16 Completed Date: 2012-08-23 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 575-80 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Discovery Sciences, Pharmacology and Toxicology, RTI International, 3040 Cornwallis Rd, Research Triangle Pk, NC 27709, USA. jmarusich@rti.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Conditioning, Operant Dose-Response Relationship, Drug Eating / drug effects, psychology Humans Male Marijuana Smoking / adverse effects, psychology Models, Animal Motivation / drug effects* Piperidines / administration & dosage, pharmacology* Pyrazoles / administration & dosage, pharmacology* Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 / antagonists & inhibitors* Reinforcement (Psychology) Task Performance and Analysis Tetrahydrocannabinol / administration & dosage, pharmacology Workload |
| Grant Support | |
ID/Acronym/Agency:
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DA-016644/DA/NIDA NIH HHS; DA-03672/DA/NIDA NIH HHS; R01 DA003672-29/DA/NIDA NIH HHS; R01 DA016644-06/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 158681-13-1/rimonabant; 1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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