Document Detail


Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure.
MedLine Citation:
PMID:  22425597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its propensity to increase motivation for food consumption, marijuana use in humans has been associated with "amotivational syndrome." This "amotivational syndrome" can be characterized by a reduction in response persistence in tasks requiring sustained, but not maximal, effort. To examine this hypothesis, dose-effect functions for THC (0.03-10 mg/kg) and rimonabant (0.1-10 mg/kg) were first determined under a time-constrained PR 5 schedule. During the second phase of the study, doses of THC and rimonabant that did not affect the responses/total reinforced responses were chosen for further evaluation in a series of PR schedules with step sizes of PR 3, PR 5, PR 10, and PR exponential. THC and rimonabant produced decreases in responses per reinforcer, and response rate when behavior was maintained on a PR 5. Rimonabant also decreased session length. During the PR step size manipulation phase, rimonabant decreased responses/total reinforced responses, response rate, and session length, whereas THC only decreased response rate. These results are consistent with previous literature demonstrating that rimonabant decreases motivation for food both in cases where it is earned, as well as under free-feeding conditions, whereas the effects of cannabinoid agonists such as THC on responding for food exhibit greater dependence upon motivational and non-motivational factors, including workload and duration of the task.
Authors:
Julie A Marusich; Jenny L Wiley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-09
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  101     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-23     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Discovery Sciences, Pharmacology and Toxicology, RTI International, 3040 Cornwallis Rd, Research Triangle Pk, NC 27709, USA. jmarusich@rti.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Conditioning, Operant
Dose-Response Relationship, Drug
Eating / drug effects,  psychology
Humans
Male
Marijuana Smoking / adverse effects,  psychology
Models, Animal
Motivation / drug effects*
Piperidines / administration & dosage,  pharmacology*
Pyrazoles / administration & dosage,  pharmacology*
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
Reinforcement (Psychology)
Task Performance and Analysis
Tetrahydrocannabinol / administration & dosage,  pharmacology
Workload
Grant Support
ID/Acronym/Agency:
DA-016644/DA/NIDA NIH HHS; DA-03672/DA/NIDA NIH HHS; R01 DA003672-29/DA/NIDA NIH HHS; R01 DA016644/DA/NIDA NIH HHS; R01 DA016644-06/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 158681-13-1/rimonabant; 1972-08-3/Tetrahydrocannabinol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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