Document Detail

Riluzole use during pregnancy in a patient with amyotrophic lateral sclerosis: a case report.
MedLine Citation:
PMID:  20515588     Owner:  NLM     Status:  MEDLINE    
Pregnancy with amyotrophic lateral sclerosis (ALS) is rare and generally considered dangerous. Riluzole is the only drug approved for use in ALS, but the effect on maternal and fetal health is unknown. We describe the case of an ALS patient taking riluzole throughout pregnancy. A 34-year old Japanese woman, who had been diagnosed with probable ALS 4 years earlier, visited our hospital for abdominal distension, without knowing that she was pregnant. The patient had been taking riluzole for 2 years, inclusive of her gestational months, and we decided to continue administration of the medication. The patient delivered a normal female infant transvaginally at 38 weeks gestation. The patient's neurological status was stable 1 year after delivery and the baby had developed normally. We found that, in this case, riluzole did not cause any side-effects to the pregnant woman or her fetus.
Y Kawamichi; Y Makino; Y Matsuda; K Miyazaki; S Uchiyama; H Ohta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  38     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  720-6     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Tokyo Women's Medical University, Shinjyuku-ku, Tokyo, Japan.
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MeSH Terms
Amyotrophic Lateral Sclerosis / drug therapy*
Fetal Monitoring
Infant, Newborn
Neuroprotective Agents / therapeutic use*
Pregnancy Complications / drug therapy*
Pregnancy Outcome
Riluzole / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Neuroprotective Agents; 1744-22-5/Riluzole

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