| Riluzole use during pregnancy in a patient with amyotrophic lateral sclerosis: a case report. | |
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MedLine Citation:
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PMID: 20515588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy with amyotrophic lateral sclerosis (ALS) is rare and generally considered dangerous. Riluzole is the only drug approved for use in ALS, but the effect on maternal and fetal health is unknown. We describe the case of an ALS patient taking riluzole throughout pregnancy. A 34-year old Japanese woman, who had been diagnosed with probable ALS 4 years earlier, visited our hospital for abdominal distension, without knowing that she was pregnant. The patient had been taking riluzole for 2 years, inclusive of her gestational months, and we decided to continue administration of the medication. The patient delivered a normal female infant transvaginally at 38 weeks gestation. The patient's neurological status was stable 1 year after delivery and the baby had developed normally. We found that, in this case, riluzole did not cause any side-effects to the pregnant woman or her fetus. |
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Authors:
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Y Kawamichi; Y Makino; Y Matsuda; K Miyazaki; S Uchiyama; H Ohta |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 720-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Tokyo Women's Medical University, Shinjyuku-ku, Tokyo, Japan. yayokawa0227@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amyotrophic Lateral Sclerosis / drug therapy* Female Fetal Monitoring Humans Infant, Newborn Neuroprotective Agents / therapeutic use* Pregnancy Pregnancy Complications / drug therapy* Pregnancy Outcome Riluzole / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 1744-22-5/Riluzole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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