| Riluzole disrupts autoresuscitation from hypothermic respiratory arrest in neonatal hamsters but not rats. | |
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MedLine Citation:
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PMID: 19442934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of riluzole on expression of the central respiratory rhythm and the ability of neonates to autoresuscitate from hypothermic respiratory arrest using in vitro brainstem-spinal cord preparations of rats and hamsters. At a constant temperature of 27 degrees C, riluzole (5-200 microM) decreased the burst amplitude of respiratory-related motor discharge, but had little effect on the fictive respiratory frequency in rat preparations. In contrast, in hamster preparations, riluzole reduced fictive respiratory frequency, but had little effect on burst amplitude. Hamster preparations were more cold-tolerant than rat preparations, with respiratory arrest and autoresuscitation occurring at lower temperatures during cooling of the preparation. This difference was removed by incubation with riluzole (5 microM); riluzole significantly increased the temperature at which fictive respiration arrested and restarted in hamster preparations, but had no effect in rat preparations. The species differences observed in this study may reflect fundamental differences in the relative role of riluzole-sensitive mechanisms in the expression of the respiratory rhythm in early development of an altricial vs. a more precocial species. |
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Authors:
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Angelina Y Fong; Lieneke H Marshall; William K Milsom |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2009-03-20 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 166 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 175-83 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of British Columbia, 6270 University Blvd., Vancouver, BC, Canada V6T 1Z4. fong@zoology.ubc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Age Factors Analysis of Variance Animals Animals, Newborn Brain Stem / drug effects Cricetinae Disease Models, Animal Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists / pharmacology* Hypothermia / physiopathology* Rats Rats, Sprague-Dawley Recovery of Function / drug effects* Respiratory Center / drug effects Respiratory Mechanics / drug effects* Resuscitation Riluzole / pharmacology* Spinal Cord / drug effects Temperature |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acid Antagonists; 1744-22-5/Riluzole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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