Document Detail


Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium.
MedLine Citation:
PMID:  8285249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Controversy exists as to the effect of endurance training on myocardial antioxidant enzyme activity. These experiments sought to clarify this issue by examining antioxidant enzyme activities in the rat ventricular myocardium in response to different intensities and durations of exercise training. Female Fischer-344 rats (120 days old) were assigned to either a sedentary control group or one of nine exercise training groups. Animals were exercised on a motorized treadmill for 10 wk; combinations of three durations (30, 60, and 90 min/day), and three levels of exercise intensity (low, moderate, and high) were studied. Exercise training did not alter (P > 0.05) citrate synthase, catalase, or glutathione peroxidase activities in the right or left ventricle. In contrast, high-intensity exercise (all durations) and moderate-intensity exercise (90 min/day) resulted in a significant increase (P < 0.05; +28-30%) in right ventricular superoxide dismutase (SOD) activity. Similarly, high-intensity exercise training (all durations) resulted in a significant elevation (P < 0.05; +14-26%) of left ventricular SOD activity. Furthermore, low- and moderate-intensity exercise training of long duration (i.e., 60-90 min/day) resulted in significant increases (P < 0.05; +10-23%) in left ventricular SOD activity. These data support the hypothesis that high-intensity exercise (> or = 30 min/day) or moderate-intensity exercise of long duration (> or = 60 min/day) is effective in upregulating SOD activity in the ventricular myocardium.
Authors:
S K Powers; D Criswell; J Lawler; D Martin; F K Lieu; L L Ji; R A Herb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2094-8     Citation Subset:  IM; S    
Affiliation:
Department of Exercise and Sport Sciences, University of Florida, Gainesville 32611.
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalase / metabolism
Female
Glutathione Peroxidase / metabolism
Heart Ventricles
Motor Activity / physiology
Muscles / metabolism
Myocardium / enzymology*
Oxidation-Reduction
Physical Conditioning, Animal*
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism*
Chemical
Reg. No./Substance:
EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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