Document Detail


Rigidity matching between cells and the extracellular matrix leads to the stabilization of cardiac conduction.
MedLine Citation:
PMID:  22325259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biomechanical dynamic interactions between cells and the extracellular environment dynamically regulate physiological tissue behavior in living organisms, such as that seen in tissue maintenance and remodeling. In this study, the substrate-induced modulation of synchronized beating in cultured cardiomyocyte tissue was systematically characterized on elasticity-tunable substrates to elucidate the effect of biomechanical coupling. We found that myocardial conduction is significantly promoted when the rigidity of the cell culture environment matches that of the cardiac cells (4 kiloPascals). The stability of spontaneous target wave activity and calcium transient alternans in high frequency-paced tissue were both enhanced when the cell substrate and cell tissue showed the same rigidity. By adapting a simple theoretical model, we reproduced the experimental trend on the rigidity matching for the synchronized excitation. We conclude that rigidity matching in cell-to-substrate interactions critically improves cardiomyocyte-tissue synchronization, suggesting that mechanical coupling plays an essential role in the dynamic activity of the beating heart.
Authors:
Marcel Hörning; Satoru Kidoaki; Takahito Kawano; Kenichi Yoshikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-07
Journal Detail:
Title:  Biophysical journal     Volume:  102     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-06-15     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Physics, Graduate School of Science, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Biomechanics
Calcium Signaling
Cytosol / metabolism
Extracellular Matrix / metabolism*
Heart Conduction System / physiology*
Mechanical Processes*
Myocytes, Cardiac / cytology*,  physiology*
Rats
Rats, Wistar
Time Factors
Comments/Corrections
Erratum In:
Biophys J. 2013 May 7;104(9):2110

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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