Document Detail

Right ventricular versus biventricular antitachycardia pacing in the termination of ventricular tachyarrhythmia in patients receiving cardiac resynchronization therapy: the ADVANCE CRT-D trial.
MedLine Citation:
PMID:  16684023     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this investigation is to compare the efficacy of antitachycardia pacing (ATP) delivered via the right ventricular (RV) lead versus ATP delivered simultaneously via the right and left ventricular leads (biventricular [BiV]) in the termination of ventricular tachyarrhythmia (VT) in patients receiving cardiac resynchronization therapy (CRT) with ICD capabilities. METHODS AND RESULTS: The ADVANCE CRT is a prospective, multicenter, randomized, parallel trial evaluating RV versus BiV ATP in the termination of VT in CRT patients. The study will test the hypothesis that BiV ATP is superior to RV ATP in the termination of VT and fast VT. All patients with class I and IIa indications for an ICD implantation and CRT are included. The sample size has been estimated to 400 participants followed for 12 months to show a 10% benefit of BiV versus RV ATP. The efficacy of BiV ATP to terminate all VT presents the primary endpoint. The investigation is expected to be completed in 2007. CONCLUSIONS: The ADVANCE CRT trial is the first large randomized clinical investigation evaluating the efficacy of BiV ATP in patients under CRT and ICD therapy.
Joerg O Schwab; Maurizio Gasparini; Frédéric Anselme; Philippe Mabo; Rafael Peinado; Thomas Lavergne; Mario Bocchiardo; Giosuè Mascioli; Micaela Passardi; Marc Mainardis
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  17     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  504-7     Citation Subset:  IM    
Department of Medicine-Cardiology, University of Bonn, Bonn, Germany.
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MeSH Terms
Aged, 80 and over
Cardiac Pacing, Artificial / statistics & numerical data*
Combined Modality Therapy / statistics & numerical data
Europe / epidemiology
Middle Aged
Prospective Studies
Randomized Controlled Trials as Topic*
Risk Assessment / methods*
Risk Factors
Tachycardia, Ventricular / epidemiology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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