Document Detail


Right ventricular systolic pressure response during exercise in adolescents born with atrial or ventricular septal defect.
MedLine Citation:
PMID:  20494671     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our study investigated the abnormal right ventricular systolic pressure response (RVPR) in young patients with isolated atrial septal defect (ASD) or ventricular septal defect (VSD). An abnormal RVPR >50 mm Hg during exercise has been identified as a precursor of pulmonary artery hypertension. The present study included a population-based selection of 44 patients (age 13 to 25 years) with either isolated VSD (n = 27) or ASD (n = 17) and without right ventricular outflow tract obstruction. Of the 44 defects, 28 had been surgically closed (17 ASDs and 11 VSDs); 16 minor VSDs were untreated. Cardiovascular exercise testing and echocardiography at rest and during exercise were performed for all patients and 88 healthy controls. The aerobic capacity was significantly reduced in all patient groups (open VSD, closed VSD, closed ASD). The measurements of right ventricular performance were significantly lower in patients with closed ASD or closed VSD compared to those of the controls and patients with open VSD. Finally, 5% of the controls, no patient with ASD, and 9 patients with VSD (33%), regardless of defect closure, had an abnormal RVPR during exercise. In conclusion, 1/3 of young patients with isolated VSD had an abnormal RVPR during exercise.
Authors:
Thomas Möller; Henrik Brun; Per Morten Fredriksen; Henrik Holmstrøm; Kari Peersen; Eirik Pettersen; Ekkehard Grünig; Derliz Mereles; Erik Thaulow
Publication Detail:
Type:  Journal Article     Date:  2010-04-02
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1610-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway. thomas.moller@siv.no
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Algorithms
Blood Pressure*
Case-Control Studies
Echocardiography
Exercise Test*
Female
Heart Septal Defects, Atrial / physiopathology*,  ultrasonography
Heart Septal Defects, Ventricular / physiopathology*,  ultrasonography
Heart Ventricles / physiopathology*,  ultrasonography
Humans
Male
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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