| Right ventricular systolic pressure response during exercise in adolescents born with atrial or ventricular septal defect. | |
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MedLine Citation:
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PMID: 20494671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our study investigated the abnormal right ventricular systolic pressure response (RVPR) in young patients with isolated atrial septal defect (ASD) or ventricular septal defect (VSD). An abnormal RVPR >50 mm Hg during exercise has been identified as a precursor of pulmonary artery hypertension. The present study included a population-based selection of 44 patients (age 13 to 25 years) with either isolated VSD (n = 27) or ASD (n = 17) and without right ventricular outflow tract obstruction. Of the 44 defects, 28 had been surgically closed (17 ASDs and 11 VSDs); 16 minor VSDs were untreated. Cardiovascular exercise testing and echocardiography at rest and during exercise were performed for all patients and 88 healthy controls. The aerobic capacity was significantly reduced in all patient groups (open VSD, closed VSD, closed ASD). The measurements of right ventricular performance were significantly lower in patients with closed ASD or closed VSD compared to those of the controls and patients with open VSD. Finally, 5% of the controls, no patient with ASD, and 9 patients with VSD (33%), regardless of defect closure, had an abnormal RVPR during exercise. In conclusion, 1/3 of young patients with isolated VSD had an abnormal RVPR during exercise. |
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Authors:
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Thomas Möller; Henrik Brun; Per Morten Fredriksen; Henrik Holmstrøm; Kari Peersen; Eirik Pettersen; Ekkehard Grünig; Derliz Mereles; Erik Thaulow |
Publication Detail:
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Type: Journal Article Date: 2010-04-02 |
Journal Detail:
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Title: The American journal of cardiology Volume: 105 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1610-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway. thomas.moller@siv.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Algorithms Blood Pressure* Case-Control Studies Echocardiography Exercise Test* Female Heart Septal Defects, Atrial / physiopathology*, ultrasonography Heart Septal Defects, Ventricular / physiopathology*, ultrasonography Heart Ventricles / physiopathology*, ultrasonography Humans Male Systole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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