Document Detail

Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis.
MedLine Citation:
PMID:  20131025     Owner:  NLM     Status:  MEDLINE    
One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumped-parameter state-variable equations. We varied the RV stiffness constant (B (RV)) to simulate the various RV hypoplasia, and estimated hemodynamics for a given B (RV). With B (RV) < 150% of normal, cardiac output was the largest in 2VR. With B (RV) > 150%, cardiac output became larger in 1.5VR than in 2VR. With B (RV) > 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
Shuji Shimizu; Toshiaki Shishido; Dai Une; Atsunori Kamiya; Toru Kawada; Shunji Sano; Masaru Sugimachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-04
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  60     ISSN:  1880-6562     ISO Abbreviation:  J Physiol Sci     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan.
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MeSH Terms
Cardiac Output
Cardiomyopathies / physiopathology,  surgery
Fontan Procedure
Heart / physiopathology*
Heart Catheterization
Heart Defects, Congenital / physiopathology,  surgery*
Heart Ventricles / abnormalities*,  physiopathology,  surgery*
Musculoskeletal Abnormalities / physiopathology,  surgery
Postoperative Period

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