| Right ventricular remodeling and dysfunction with subsequent annular dilatation and tethering as a mechanism of isolated tricuspid regurgitation. | |
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MedLine Citation:
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PMID: 18728332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Secondary tricuspid regurgitation (TR) as a result of pulmonary hypertension and/or left-sided heart disease is caused by tricuspid valve (TV) annular dilatation and tethering of the tricuspid leaflet after right ventricular (RV) dilatation. However, the mechanism of isolated TR without significant pulmonary hypertension remains unknown. The present study investigated the RV function and TV deformations in patients with isolated TR to find out the mechanism and etiology of the disease. METHODS AND RESULTS: Twelve patients with isolated, severe TR were included. RV area, volume, ejection fraction (EF), tenting distance and tenting area were measured. These parameters were compared with 12 age-and gender-matched controls and 12 patients with secondary TR. The cause of isolated TR was incomplete coaptation associated with annular dilatation without other problems. Compared with the controls, RV end-diastolic volumes and annular diameters were significantly larger and RVEF was significantly lower in patients with isolated TR. Tenting area and tenting distance were also significantly higher. However, there were no significant differences in these parameters between patients with isolated and secondary TR. CONCLUSIONS: Isolated TR was associated with RV remodeling, systolic dysfunction and resultant annular dilatation and tethering of tricuspid leaflets. |
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Authors:
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Hye-Sun Seo; Jong-Won Ha; Jae Youn Moon; Eui-Young Choi; Se-Joong Rim; Yangsoo Jang; Namsik Chung; Won-Heum Shim; Seung-Yun Cho; Sung Soon Kim |
Publication Detail:
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Type: Journal Article Date: 2008-08-27 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-26 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1645-9 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dilatation, Pathologic
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physiopathology Echocardiography Humans Retrospective Studies Tricuspid Valve Insufficiency / physiopathology*, ultrasonography Ventricular Dysfunction, Right / pathology, physiopathology*, ultrasonography Ventricular Function, Right / physiology* Ventricular Remodeling / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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