Document Detail

Right ventricular outflow tract obstruction due to extrinsic compression by non-Hodgkin's lymphoma: importance of echocardiographic diagnosis and follow up.
MedLine Citation:
PMID:  1282429     Owner:  NLM     Status:  MEDLINE    
Acquired right ventricular outflow tract obstruction due to extrinsic compression of the pulmonary artery is a rare manifestation of non-Hodgkin's lymphoma (NHL). We report a case of a 17 year old boy who was referred for evaluation of a large anterior mediastinal mass, causing dyspnea and cough and resulting in a harsh systolic murmur. Echocardiography demonstrated compression of the pulmonary artery by the mass, with a severe pressure gradient. Biopsy revealed intermediate grade, diffuse large cell NHL. Systemic chemotherapy rapidly led to a significant decrease in the size of the mass, and virtual disappearance of the pressure gradient. In this report, the use of echocardiography for diagnosis and follow up of extracardiac tumors is reviewed. It is suggested that this technique may also be useful for the routine staging of mediastinal lymphomas because of the potential consequences of clinically undetectable hemodynamic compromise.
C Putterman; D Gilon; G Uretzki; J Bar-Ziv; A Polliack
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  7     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bleomycin / administration & dosage
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Etoposide / administration & dosage
Lymphoma, Non-Hodgkin / complications*,  drug therapy,  physiopathology
Prednisone / administration & dosage
Pulmonary Valve Stenosis / etiology,  physiopathology,  ultrasonography*
Ventricular Function
Vincristine / administration & dosage
Reg. No./Substance:
0/VACOP-B protocol; 11056-06-7/Bleomycin; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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