| Right ventricular involvement in anterior myocardial infarction: a translational approach. | |
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MedLine Citation:
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PMID: 20304784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim of the present study was to evaluate the involvement of the right ventricle (RV) in reperfused anterior ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: Left anterior descending (LAD)-perfused area (using thioflavin-S staining after selective infusion in proximal LAD artery, %), infarct size (using triphenyltetrazolium chloride staining, %), and salvaged myocardium (% of LAD-perfused area) in the right and left ventricle (LV) were quantified in a 90-min LAD occlusion 3-day reperfusion model in swine (n = 8). Additionally, we studied, using cardiovascular magnetic resonance, 20 patients with a first STEMI due to proximal LAD occlusion treated with primary angioplasty. Area at risk (T2-weighted sequence, %), infarct size (late enhancement imaging, %), and salvaged myocardium (% of area at risk) in the right and LV were quantified. In swine, a large LAD-perfused area was detected both in the right and LV (30 +/- 5 vs. 62 +/- 15%, P< 0.001) but more salvaged myocardium (94 +/- 6 vs. 73 +/- 11%, P< 0.001) resulted in a smaller right ventricular infarct size (2 +/- 1 vs. 16 +/- 5%, P< 0.001). Similarly, in patients a large area at risk was detected both in the right and LV (34 +/- 13 vs. 43 +/- 12%, P = 0.02). More salvaged myocardium (94 +/- 10 vs. 33 +/- 26%, P < 0.001) resulted in a smaller infarct size (2 +/- 3 vs. 30 +/- 16%, P< 0.001) in the RV. CONCLUSION: In reperfused extensive anterior STEMI, a large area of the RV is at risk but the resultant infarct size is small. |
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Authors:
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Vicente Bodi; Juan Sanchis; Luis Mainar; Francisco J Chorro; Julio Nunez; Jose V Monmeneu; Fabian Chaustre; Maria J Forteza; Amparo Ruiz-Sauri; Maria P Lopez-Lereu; Cristina Gomez; Inmaculada Noguera; Ana Diaz; Francisco Giner; Angel Llacer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: Cardiovascular research Volume: 87 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 601-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, Valencia 46010, Spain. vicentbodi@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary Animals Anterior Wall Myocardial Infarction / pathology*, physiopathology, therapy Autopsy Coronary Circulation Disease Models, Animal Female Heart Ventricles / pathology, physiopathology Humans Magnetic Resonance Imaging, Cine Male Middle Aged Myocardium / pathology* Prospective Studies Sus scrofa Translational Research* Treatment Outcome Ventricular Function, Left Ventricular Function, Right |
| Comments/Corrections | |
Comment In:
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Cardiovasc Res. 2010 Sep 1;87(4):585-6
[PMID:
20631157
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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