Document Detail

Right ventricular hypertrophy in tetralogy of Fallot.
MedLine Citation:
PMID:  145637     Owner:  NLM     Status:  MEDLINE    
Histopathological studies were carried out on right ventricular myocardium in 104 patients with tetralogy of Fallot (T/F). Detailed analysis of the correlation between morphological and clinical data was performed. Right ventricular hypertrophy in T/F was found to initiate immediately after birth, and the diameter of right ventricular muscle fiber (D) increased with age (r = 0.74). There was a correlation between D and the hemoglobin level. There was, however, no correlation between D arterial oxygen saturation (SaO2), and pulmonary trunk/aorta diameter (PA/Ao) ratio. Histopathological alterations were related directly to D and to the age of the patient, and were unrelated to hemoglobin, SaO2, and PA/Ao ratio. Irreversible histopathological alterations were first observed when the D exceeded 15 micron, when most patients were four years old or more. From these findings, it is considered that the optimal age for corrective surgery to prevent irreversible alteration of the right ventricular muscle fibers in patients with T/F is less than three years.
M Kato; Y Kawashima; T Fujita; T Mori; H Manabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  12     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:    1976 May 26-29
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
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MeSH Terms
Age Factors
Cardiomegaly / etiology,  pathology*,  physiopathology
Child, Preschool
Heart / physiopathology
Infant, Newborn
Myocardium / pathology*
Tetralogy of Fallot / complications,  pathology*,  physiopathology

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