Document Detail

Right ventricular function in scleroderma-related pulmonary hypertension.
MedLine Citation:
PMID:  18784141     Owner:  NLM     Status:  MEDLINE    
SSc-associated pulmonary arterial hypertension (PAH) has a poorer prognosis than that of other types of pulmonary hypertension. Recent echocardiographic and haemodynamic studies suggest that right ventriculer (RV) pump function and filling characteristics are altered in SSc-PAH as compared with idiopathic PAH. This could be explained by intrinsic myocardial involvement of the disease, related to abnormal collagen deposition, also observed in the left ventricle, or an increased vulnerability to ischaemia due to coronary vasculopathy, abnormal collagen cross-linking and altered myocyte function. It is also possible that a relatively more important decrease in pulmonary arterial compliance as evidenced by recently reported increased characteristic impedance measurements, would contribute to RV-arterial decoupling. More pathological, imaging and haemodynamic studies are needed for a better understanding for relatively more important vulnerability of the RV in SSc-PAH.
A Vonk Noordegraaf; R Naeije
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  47 Suppl 5     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-11     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  v42-3     Citation Subset:  AIM; IM    
Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Hypertension, Pulmonary / pathology,  physiopathology*,  ultrasonography
Myocardium / pathology
Scleroderma, Systemic / pathology,  physiopathology*,  ultrasonography
Stroke Volume
Ventricular Dysfunction, Right / pathology,  physiopathology*,  ultrasonography
Ventricular Pressure

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