| Right ventricular function in scleroderma-related pulmonary hypertension. | |
| | |
MedLine Citation:
|
PMID: 18784141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
SSc-associated pulmonary arterial hypertension (PAH) has a poorer prognosis than that of other types of pulmonary hypertension. Recent echocardiographic and haemodynamic studies suggest that right ventriculer (RV) pump function and filling characteristics are altered in SSc-PAH as compared with idiopathic PAH. This could be explained by intrinsic myocardial involvement of the disease, related to abnormal collagen deposition, also observed in the left ventricle, or an increased vulnerability to ischaemia due to coronary vasculopathy, abnormal collagen cross-linking and altered myocyte function. It is also possible that a relatively more important decrease in pulmonary arterial compliance as evidenced by recently reported increased characteristic impedance measurements, would contribute to RV-arterial decoupling. More pathological, imaging and haemodynamic studies are needed for a better understanding for relatively more important vulnerability of the RV in SSc-PAH. |
| | |
Authors:
|
A Vonk Noordegraaf; R Naeije |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Rheumatology (Oxford, England) Volume: 47 Suppl 5 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-09-11 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
|
Languages: eng Pagination: v42-3 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. A.Vonk@VUmc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Echocardiography Humans Hypertension, Pulmonary / pathology, physiopathology*, ultrasonography Myocardium / pathology Scleroderma, Systemic / pathology, physiopathology*, ultrasonography Stroke Volume Ventricular Dysfunction, Right / pathology, physiopathology*, ultrasonography Ventricular Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcome measures in pulmonary arterial hypertension associated with systemic sclerosis.
Next Document: Skin involvement in systemic sclerosis.